Unlocking the secrets of aging: Epigenetic reader BRD4 as the target to combatting aging-related diseases

Sun, Jiaxing; Gui, Yu; Zhou, Shenghua; Zheng, Xi-Long

doi:10.1016/j.jare.2023.11.006

Cited by 6 publications

(1 citation statement)

References 154 publications

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“…However, it has also been reported that exposure of healthy male mice and rats to the BRD2-3-4 IBET-151 damaged cardiac mitochondria and led to dilated cardiomyopathy [93]. These contrasting results might imply (i) indirect cardiac effect of pharmacological intervention, (ii) off-target extracardiac effects, and (iii) discrepancy in the in vivo/in vitro models [94]. The first two points are particularly valid for pan-BETi, which still fails the clinical translation in humans due to toxicity [92].…”

Section: Epigenetic Readers: Bromodomain and Extraterminal Domain (Be...mentioning

confidence: 99%

Novel Techniques, Biomarkers and Molecular Targets to Address Cardiometabolic Diseases

Di Fiore,

Cappelli,

Del Punta

et al. 2024

JCM

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Cardiometabolic diseases (CMDs) are interrelated and multifactorial conditions, including arterial hypertension, type 2 diabetes, heart failure, coronary artery disease, and stroke. Due to the burden of cardiovascular morbidity and mortality associated with CMDs’ increasing prevalence, there is a critical need for novel diagnostic and therapeutic strategies in their management. In clinical practice, innovative methods such as epicardial adipose tissue evaluation, ventricular–arterial coupling, and exercise tolerance studies could help to elucidate the multifaceted mechanisms associated with CMDs. Similarly, epigenetic changes involving noncoding RNAs, chromatin modulation, and cellular senescence could represent both novel biomarkers and targets for CMDs. Despite the promising data available, significant challenges remain in translating basic research findings into clinical practice, highlighting the need for further investigation into the complex pathophysiology underlying CMDs.

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Section: Epigenetic Readers: Bromodomain and Extraterminal Domain (Be...mentioning

confidence: 99%