Unlocking traditional remedy: Gulkand-enhanced mucoadhesive gel for canker sore relief

Abstract

This study focuses on the development and evaluation of mucoadhesive gel formulations containing different Gulkand and its extract with a specific emphasis on their potential for managing oral health conditions, including the discomforting issue of mouth ulcers. The formulations underwent a thorough analysis, encompassing the assessment of phenolic compounds responsible for antioxidant activity, in addition to comprehensive physical, chemical, and pharmacological evaluations to determine their suitability for commercial utilization. Mouth ulcers are a prevalent oral health concern that can cause significant discomfort and inconvenience. In this study, Gulkand extract exhibited remarkable characteristics with its high phenolic content and robust antioxidant activity. It demonstrated rapid drug release, positioning it as a promising new for addressing the immediate relief needs of individuals suffering from mouth ulcers. Conversely, gel formulation showcased a sustained release profile suggesting the potential for longer therapeutic benefits, presents an intriguing option for oral health applications, capitalizing on the antiulcer properties associated with liquorice. An innovative aspect of this study is the compatibility assessment, which employed antioxidant and phenolic content analysis to verify the harmonious interaction between herbal constituents and excipients. This approach introduces novel perspective on compatibility testing, particularly critical for formulations designed to alleviate oral discomfort effectively. Furthermore, stability studies are warranted to be evaluated prior to their potential for commercialization. The present study revealed the promising potential of the prepared mucoadhesive gels in managing not only mouth ulcers but also a spectrum of oral health conditions, holding broader implications for advancements in the field of medicine.