This chapter addresses the critical issues of safety, ethics, and regulation surrounding the deployment of AI in industrial robotics and intelligent drones. It highlights the importance of establishing robust safety standards to mitigate risks associated with mechanical and software failures. Ethical considerations are explored, focusing on accountability, privacy, and the socio-economic impacts of automation. The chapter also navigates the complex regulatory landscape, underscoring the need for adaptive frameworks that balance innovation with public safety. Through case studies and discussions, it calls for a multidisciplinary approach to develop ethical guidelines and effective legislation. The chapter emphasizes the collective responsibility of stakeholders to ensure the responsible advancement of AI technologies, advocating for policies that protect human welfare while fostering technological growth.