- In current scenario, where individuals spend the majority of their time indoors, the quality of the indoor air has become increasingly crucial. This research paper investigates the role of optimizing Indoor Air Quality (IAQ) as a proactive strategy for mitigating Sick Building Syndrome (SBS) within built environments. It examines the relationship between indoor air quality (IAQ) and Sick Building Syndrome (SBS) in workplace settings and explores strategies for enhancing IAQ to mitigate SBS symptoms. Indoor air quality (IAQ) significantly impacts human health and well-being, with implications for productivity, comfort, and overall quality of life. To ensure safe and healthy indoor environments, various organizations, including the World Health Organization (WHO), Environmental Protection Agency (EPA), and Occupational Safety and Health Administration (OSHA), have established IAQ standards and guidelines. This research aims to conduct a comprehensive analysis of these standards. Moreover, the multifaceted nature of IAQ management is explored through the inclusion of parameters like radon (Rn), relative humidity (RH), and temperature. These factors not only contribute to indoor air quality but also affect occupants' comfort and well-being. By considering both chemical and environmental factors. Key Words: Indoor air quality, mitigate, policies, Sick building syndrome