Unmasking the complex roles of hypocalcemia in cancer, COVID-19, and sepsis: Engineered nanodelivery and diagnosis

Ghafouri, Elham; Bigdeli, Mandana; Khalafiyan, Anis; Amirkhani, Zohre; Ghanbari, Roham; Hasan, Anwarul; Khanahmad, Hossein; Boshtam, Maryam; Makvandi, Pooyan

doi:10.1016/j.envres.2023.116979

Environmental Research

2023

DOI: 10.1016/j.envres.2023.116979

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Unmasking the complex roles of hypocalcemia in cancer, COVID-19, and sepsis: Engineered nanodelivery and diagnosis

Elham Ghafouri,

Mandana Bigdeli,

Anis Khalafiyan

et al.

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2024

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Cited by 3 publications

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Establishment and evaluation of nomogram for predicting acute respiratory distress syndrome in meconium‐stained amniotic fluid neonates

Shen,

Wan,

Sun

et al. 2024

Pediatric Pulmonology

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ObjectiveTo delineate risk factors and develop a predictive nomogram for acute respiratory distress syndrome (ARDS) in neonates exposed to meconium‐stained amniotic fluid (MSAF).MethodsWe conducted a comprehensive retrospective analysis of neonates with MSAF, classifying them into ARDS and non‐ARDS groups based on the onset of ARDS within the first week after birth. Clinical and laboratory data are collected to screen the risk factors for ARDS in MSAF neonates, multivariate logistic regression was performed to identify independent predictors and establish a nomogram to predict the occurrence of neonatal ARDS.ResultsWe recognized five variables as independent risk factors for ARDS with MSAF neonates via logistic regression analysis, consisting of 1‐min Apgar score (Apgar 1 min), white blood cell (WBC), platelet (PLT), red cell distribution width (RDW) and serum calcium (Ca). These predictors were integrated into a nomogram designed to estimate the individual risk of ARDS development in neonates. The predictive model achieved a C‐index of 0.942 (95% CI: 0.915‐0.970), indicating high predictive accuracy. Additionally, the nomogram was internally validated, demonstrating excellent calibration and practical utility for clinical decision‐making.ConclusionsThe validated nomogram, based on five pivotal factors, provides clinicians with a reliable tool for early identification and management of ARDS in MSAF neonates, potentially improving outcomes by facilitating timely and appropriate therapeutic interventions.

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Establishment and evaluation of nomogram for predicting acute respiratory distress syndrome in meconium‐stained amniotic fluid neonates

Shen,

Wan,

Sun

et al. 2024

Pediatric Pulmonology

View full text Add to dashboard Cite

show abstract

Hypocalcemia in critical care settings, from its clinical relevance to its treatment: A narrative review

Fernandes,

Pereira

2024

Anaesthesia Critical Care & Pain Medicine

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Association between serum calcium levels and in-hospital mortality in sepsis: A retrospective cohort study

Wang,

Sun,

Sun

2024

Heliyon

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Unmasking the complex roles of hypocalcemia in cancer, COVID-19, and sepsis: Engineered nanodelivery and diagnosis

Cited by 3 publications

References 147 publications

Establishment and evaluation of nomogram for predicting acute respiratory distress syndrome in meconium‐stained amniotic fluid neonates

Establishment and evaluation of nomogram for predicting acute respiratory distress syndrome in meconium‐stained amniotic fluid neonates

Hypocalcemia in critical care settings, from its clinical relevance to its treatment: A narrative review

Association between serum calcium levels and in-hospital mortality in sepsis: A retrospective cohort study

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