Unmet Needs, Barriers, and Facilitators for Conducting Adolescent and Young Adult Cancer Survivorship Research in Southern California: A Delphi Survey

Chan, Alexandre; Ports, Kayleen; Ng, Ding Quan; Nasr, Reem; Hsu, Steffi; Armenian, Saro H.; Baca, Nicole; Freyer, David R.; Kuo, Dennis John; Lin, Carol; Milam, Joel; Valerin, Jennifer; Yun, Christine; Torno, Lilibeth

doi:10.1089/jayao.2022.0086

Cited by 5 publications

(3 citation statements)

References 24 publications

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“…Prior studies have suggested overcoming recruitment barriers and increasing awareness of ongoing trials for enrollment of AYAC [33]. Potential strategies to increase AYAC recruitment in future trials include improving communication between patients and clinicians [33], actively addressing the barriers to recruitment [45 ▪▪ ]. IO modalities, being scarcely available, needs resources to conduct trials [46].…”

Section: Discussionmentioning

confidence: 99%

Current evidence of integrative oncology modalities for managing adverse effects and survivorship issues among adolescents and young adult (AYA) cancer patients and survivors

Yusuf,

Ng,

Torno

et al. 2024

Current Opinion in Oncology

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Purpose of the review Symptom burden of cancer diagnosis and treatment has led adolescents and young adult cancer patients (AYAC) and survivors to seek different self-management strategies including integrative oncology (IO) modalities. IO holds great promise to improve survivorship issues in adolescents and young adult (AYA) cancer survivors. This review aims to encompass the current evidence of IO modalities and to analyze the efficacy of IO for managing survivorship issues among AYA cancer patients and survivors. Recent findings Nineteen randomized controlled trials included in this review evaluated mind and body modalities including both physical and psychological (74%) and psychological only (26%) modalities. Most assessed IO modalities were physical activity (PA) (37%) and structured exercise (10%). Most effective IO modalities found were PA, massage, mindfulness-based stress reduction (MBSR) and light therapy for treating AYA symptom burden. The Cochrane risk of bias (RoB-2) concluded 21% studies had high risk, 58% possessed some concerns and 21% had low risk. Summary Although evidence has shown that a number of IO modalities may improve survivorship among AYA cancer survivors, more rigorous study designs are needed in order for these modalities to be routinely recommended for use in clinical practice.

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Section: Discussionmentioning

confidence: 99%

Current evidence of integrative oncology modalities for managing adverse effects and survivorship issues among adolescents and young adult (AYA) cancer patients and survivors

Yusuf,

Ng,

Torno

et al. 2024

Current Opinion in Oncology

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“…Symptoms are presented as difficulties with memory, executive function, processing speed, and attention, leading to challenges in the pursuit of higher education, management of personal finances, and fulfilling family and work responsibilities [ 1 , 2 , 3 ]. Causes of CRCI have been documented to be multifactorial in nature, and hence it remains a significant quality of life issue and an unmet need among cancer survivors due to its limited management options [ 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Research Attitude and Interest among Cancer Survivors with or without Cognitive Impairment

Chan

Acharya

et al. 2023

Cancers

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Background: We examined the research attitudes and willingness to participate in clinical research among cancer survivors with varying degrees of cognitive function. Methods: This is a secondary analysis of data collected through the University of California Irvine Consent-to-Contact registry. Cancer survivors completed the Cognitive Function Instrument (CFI), the Research Attitudes Questionnaire (RAQ), and willingness to participate (WTP) in certain research procedures. Perceived cognitive impairment (CI) was defined as the worst 20% CFI scores. Results: Here, 265 CI and 909 cognitively non-impaired (CNI) participants’ data were analyzed. Mean age and sex distribution were similar, with fewer non-Hispanic Whites and education years among CI participants. More CI participants self-reported past diagnoses of Alzheimer’s disease, mild cognitive impairment, stroke, depression, post-traumatic stress disorder, and alcohol abuse (all p < 0.05). CI participants were significantly more interested in studies investigating approved medications (92% vs. 87%, p = 0.030), lumbar puncture (47% vs. 38%, p = 0.027), and autopsy (78% vs. 69%, p = 0.022). After removing survivors with co-existing neuropsychiatric conditions, interest in autopsy studies remained statistically higher among CI (79% vs. 69%, p = 0.022). Conclusions: Participants with cancer and CI are open to research procedures and interventions that are traditionally less utilized, which may facilitate the discovery of the pathogenesis and interventions for cancer-related cognitive impairment (CRCI).

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“…Although the effects of CRCI may be transient or long term, cognitive decline can adversely affect patients' quality of life [7]. Clinicians have continued to identify CRCI as an ongoing unmet need in survivorship care [8].…”

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confidence: 99%

Biomarkers in the Prediction of Cancer-Related Cognitive Impairment: Implications within Supportive Care

Chan

Yusuf

et al. 2023

Research in Clinical Pharmacy

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Patients and survivors of cancer may develop cognitive impairment pre-, intra-, and posttreatment, which is a phenomenon known as cancer-related cognitive impairment (CRCI) or chemobrain. CRCI can adversely affect the quality of life in patients and survivors of cancer. Several factors are associated with CRCI, and the proposed CRCI mechanisms include oxidative stress, dysregulation of inflammatory cytokines, genetic susceptibility, hormone deficiencies and/or psychological distress. Over the past 15 years (2008-2023), our Singapore-and United States-based research team has conducted numerous human studies to evaluate the underlying mechanisms of CRCI through biomarker discovery and validation. Hence, this narrative review aims to elucidate the association between peripheral biomarkers evaluated in our past studies and cognitive function among non-CNS cancer survivors. In summary, plasma levels of brain-derived neurotrophic factor, inflammatory cytokines, and dynamin-1 in plasma extracellular vesicles have shown promising roles in CRCI pathophysiology. These findings indicate that further investigations are required to explore their potential to translate observational results into experimental therapeutics.

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Unmet Needs, Barriers, and Facilitators for Conducting Adolescent and Young Adult Cancer Survivorship Research in Southern California: A Delphi Survey

Cited by 5 publications

References 24 publications

Current evidence of integrative oncology modalities for managing adverse effects and survivorship issues among adolescents and young adult (AYA) cancer patients and survivors

Current evidence of integrative oncology modalities for managing adverse effects and survivorship issues among adolescents and young adult (AYA) cancer patients and survivors

Research Attitude and Interest among Cancer Survivors with or without Cognitive Impairment

Biomarkers in the Prediction of Cancer-Related Cognitive Impairment: Implications within Supportive Care

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