Unmet needs for relapsed or refractory Wilms tumour: Mapping the molecular features, exploring organoids and designing early phase trials – A collaborative SIOP-RTSG, COG and ITCC session at the first SIOPE meeting

Finding the way to Wilms tumor by comparing the primary and relapse tumor samples

“…Lastly, the relapse setting gives us opportunities to test new drugs (that can be moved upfront in the future), and also to develop tumor models, like organoids or patient-derived xenografts. 9 …”

Progress by international collaboration for pediatric renal tumors by HARMONIsation and Collaboration: the HARMONICA initiative

“…(11)(12)(13)(14) More recently, during the HARMONICA era, coordinated parallel manuscript/research efforts from COG/SIOP have focused on imaging surveillance, (15,16) stage 1 DAWT (17,18) and WAGR and WT. (19,20) Collaborative reviews on unmet needs in WT, (21) addressing international progress in WT, (3) WT phase 1 and 2 studies, ( 22) congenital mesoblastic nephroma, (23) renal cell carcinoma (24) Wilms tumor broadly, (25)) and more recently a comprehensive position paper on oncofertility issues pertinent to pediatric renal cancer (26) have been finalized.…”

Fifty years of clinical and research studies for childhood renal tumors within the International Society of Pediatric Oncology (SIOP)

“…Radiology Diffusion weighted MRI is helpful in characterizing renal tumors Outcome of patients with CT-only lung metastasis is inferior to no metastasis Specific renal tumors require biopsy before preoperative chemotherapy ( 14), ( The basis for the current UMBRELLA study is summarized in several reviews on Nephroblastoma, 13,37,38 relapse treatment, 39,40 pathology and biology, 41 but also on different non-WTs. [42][43][44][45][46] Over the last decades collaboration and exchange of knowledge between SIOP-RTSG and the Children's Oncology Group Renal Tumor Committee has developed resulting in a number of papers such as renal tumors of early age, 47 a meta-analysis of high dose chemotherapy, 48 late relapses, 49 the advances of international collaboration 50 and new approaches to risk stratification for WT.…”