Unmet needs in glaucoma therapy: The potential role of hydrogen sulfide and its delivery strategies

Mhatre, Susmit; Opere, Catherine A.; Singh, Somnath

doi:10.1016/j.jconrel.2022.05.001

Cited by 13 publications

(9 citation statements)

References 177 publications

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“…It is believed that the third-generation alpha-2 adrenergic agonist brimonidine tartrate, which has antiapoptotic characteristics, has neuroprotective effects. [2021] RGC survival was 50% higher in the brimonidine-treated eyes compared to the timolol-treated eyes in a chronic ocular hypertension rat paradigm [ 82 , 96 ]. Brimonidine also reduced the risk of visual field progression compared to timolol in patients suffering from glaucoma.…”

Section: Neuroprotective Agentsmentioning

confidence: 99%

Nanocarriers for the Delivery of Neuroprotective Agents in the Treatment of Ocular Neurodegenerative Diseases

et al. 2023

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Retinal neurodegeneration is considered an early event in the pathogenesis of several ocular diseases, such as diabetic retinopathy, age-related macular degeneration, and glaucoma. At present, there is no definitive treatment to prevent the progression or reversal of vision loss caused by photoreceptor degeneration and the death of retinal ganglion cells. Neuroprotective approaches are being developed to increase the life expectancy of neurons by maintaining their shape/function and thus prevent the loss of vision and blindness. A successful neuroprotective approach could prolong patients’ vision functioning and quality of life. Conventional pharmaceutical technologies have been investigated for delivering ocular medications; however, the distinctive structural characteristics of the eye and the physiological ocular barriers restrict the efficient delivery of drugs. Recent developments in bio-adhesive in situ gelling systems and nanotechnology-based targeted/sustained drug delivery systems are receiving a lot of attention. This review summarizes the putative mechanism, pharmacokinetics, and mode of administration of neuroprotective drugs used to treat ocular disorders. Additionally, this review focuses on cutting-edge nanocarriers that demonstrated promising results in treating ocular neurodegenerative diseases.

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Section: Neuroprotective Agentsmentioning

confidence: 99%

Nanocarriers for the Delivery of Neuroprotective Agents in the Treatment of Ocular Neurodegenerative Diseases

et al. 2023

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“…What is more, NO also plays a key role in host immunity and tumor suppression [ 4 ]. H 2 S plays an important role in the regulation of homeostasis of numerous systems, including the cardiovascular, neuronal, gastrointestinal, respiratory, renal, liver, reproductive, and other aspects [ 5 , 6 ]. Controlled delivery of small doses of modulate gasotransmitters in vivo are promising for numerous biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Cyclodextrin Metal-Organic Framework as a Broad-Spectrum Potential Delivery Vehicle for the Gasotransmitters

Liao

et al. 2023

Molecules

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The important role of gasotransmitters in physiology and pathophysiology suggest employing gasotransmitters for biomedical treatment. Unfortunately, the difficulty in storage and controlled delivery of these gaseous molecules hindered the development of effective gasotransmitters-based therapies. The design of a safe, facile, and wide-scale method to delivery multiple gasotransmitters is a great challenge. Herein, we use an ultrasonic assisted preparation γ-cyclodextrin metal organic framework (γ-CD-MOF) as a broad-spectrum delivery vehicle for various gasotransmitters, such as SO2, NO, and H2S. The release rate of gasotransmitters could be tuned by modifying the γ-CD-MOF with different Pluronics. The biological relevance of the exogenous gasotransmitters produced by this method is evidenced by the DNA cleavage ability and the anti-inflammatory effects. Furthermore, the γ-CD-MOF composed of food-grade γ-CD and nontoxic metal salts shows good biocompatibility and particle size (180 nm). Therefore, γ-CD-MOF is expected to be an excellent tool for the study of co-delivery and cooperative therapy of gasotransmitters.

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“…Tailoring SMS to the individualized needs of patients may enhance the e cacy of the program [16]. To date, however, most of the research on self-management has focused on the performance of selfmanagement tasks or the effectiveness of support programs for self-management while neglecting to address patients' relevant needs throughout this process [17]. Therefore, to enhance glaucoma patients' ability to manage their condition effectively, this study employs phenomenological research methods and qualitative interviews to comprehensively investigate the challenges of self-management and support needs.…”

Section: Introductionmentioning

confidence: 99%

Self-management challenges and support needs among patients with primary glaucoma: A qualitative study

Hua

Dai

et al. 2023

Preprint

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Background Self-management plays an important role in the disease management of glaucoma patients. Evidence suggests that tailoring self-management support to patients' individual needs may enhance program effectiveness. However, most research on self-management support has focused solely on the performance of self-management tasks or the efficacy of support programs, neglecting the crucial aspect of addressing patients' unique needs for self-management. Therefore, in this study, we conducted an in-depth investigation into the self-management challenges and support needs of patients with primary glaucoma, providing a basis for nursing staff to implement self-management support. Method The phenomenological method and semistructured interviews were used in this study. A total of 20 patients with primary glaucoma were recruited between June and December 2022. Colaizzi’s analysis method was used to analyse the interview data. Results Challenges for patients include becoming an expert in glaucoma, managing negative emotions, adapting to daily life changes and resuming social activities. To address these challenges, four themes of patient self-management support needs were identified:(1)health information support,༈2༉social support,༈3༉psychological support, and༈4༉daily living support. Conclusion Patients with primary glaucoma experience varying degrees of challenge in dealing with medical, emotional, and social aspects. Comprehending the support needs of patients, healthcare professionals should deliver targeted, personalized and comprehensive self-management interventions to enhance their capacity of patients to perform self-management and improve their quality of life.

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Unmet needs in glaucoma therapy: The potential role of hydrogen sulfide and its delivery strategies

Cited by 13 publications

References 177 publications

Nanocarriers for the Delivery of Neuroprotective Agents in the Treatment of Ocular Neurodegenerative Diseases

Nanocarriers for the Delivery of Neuroprotective Agents in the Treatment of Ocular Neurodegenerative Diseases

Cyclodextrin Metal-Organic Framework as a Broad-Spectrum Potential Delivery Vehicle for the Gasotransmitters

Self-management challenges and support needs among patients with primary glaucoma: A qualitative study

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