Objective: We conducted a systematic review and meta-analysis to assess the effect of unpaid caregiving by men on their labour force participation (LFP).Methods: English-language journal articles, dissertations and working/conference papers from the MEDLINE, Embase, AgeLine, EconLit, EconPapers and the International Bibliography of the Social Science databases were searched from January 2007 to February 2021. We pooled the marginal effect of caregiving on men’s LFP in a random-effects model where LFP was defined as being gainfully employed while non-LFP comprised all other circumstances. Non-parametric methods were used to estimate the probability that caregiving was negatively associated with LFP. Meta-regressions were conducted with countries stratified by Gross National Income (GNI) per capita as a moderator variable. Secondary analyses were performed on employed men to assess the potential caregiving effect on temporary work exit and permanent retirement.Results: Thirty-one studies (904,694 men) were included in the review with 28 of these studies (892,805 men) used in the meta-analysis. The random-effects model found men who were weekly, daily or primary caregivers to experience a 4.4%, 8.0% and 10.0% reduction in their LFP, when compared to their respective counterparts. We estimated weekly, daily or primary caregivers to have an 87.3% (95% CI: 70%-96%), 87.5% (95% CI: 84%-96%) and 80.8% (95% CI: 67%-100%) chance of a lower LFP. An hourly increase in caregiving was unrelated to LFP (p-value=0.106). Among employed men (24,319 men), caregiving was found to be unrelated with retirement (p-value=0.156) and no meta-analysis was conducted on temporary work exit. No difference was found across countries stratified by GNI per capita.Conclusions: These results urge policy decisionmakers to provide more flexible work arrangements and other protective measures to support male employees who are weekly, daily or primary caregivers. Future meta-analyses should explore the effect of caregiving on other dimensions of labour supply (e.g., hours of work) by men. The scarcity of studies conducted in low-/middle-income countries might be addressed by creating population-based cohorts following the protocol of existing studies such as the American HRS (Health and Retirement Study). JEL classification: J16, J20, J22, J26