Unprecedented diterpenoid dimers with soluble epoxide hydrolase inhibitory effect from Euphorbia fischeriana

Abstract

Biseuphoids A (1) and B (2), two unprecedented ent-abietane-type diterpenoid dimers linked by monomeric blocks through C-17−C-12′ and C-17−C-11′, respectively, were isolated from Euphorbia fischeriana, along with their biogenesis related...

Biogenetic and biomimetic synthesis of natural bisditerpenoids: hypothesis and practices

“…In our phytochemical studies on Euphorbia fischeriana , a traditional Chinese medicine, a series of ent -abietane-type dimers with different linkage patterns were identified ( 131–134 ). 87,88 We observed that dimers 131–134 have the same block, derived from 131b , whereas another block was connected to 131b in the α-position of their ketone groups. Therefore, it is reasonable to speculate that the dimerization forming 131–134 was a Michael addition (Scheme 12).…”

Discovery of two ent-atisane diterpenoid lactones with AChE inhibitory activity from the roots of Euphorbia fischeriana

“…The roots of E. fischeriana are named “Lang-du”, and are used as a traditional Chinese medicine to treat edema, scattered knots, insect wounds, ascites, and tinea. 9–11 Chemical constituents of the Euphorbia species have been extensively studied, leading to the isolation of a variety of diterpenoids, such as ent -kaurane, 12 tigliane, 13 ent -abietane, 14 ent -atisane, 15 lathyrane, 16 ingol, 17 rosane, 18 and jatrophane types, 8 as well as norditerpenoids, 19,20 dimeric diterpenoids, 21–23 and meroterpenoids. 24 Previous studies have shown that the extracts and some terpenoids isolated from E. fischeriana showed significant AChE inhibitory activity.…”

Diterpenoids from Euphorbia fischeriana with Kv1.3 Inhibitory Activity

“…E. fischeriana is a perennial plant that is mainly distributed in northeastern China. As a traditional Chinese medicine, E. fischeriana has long been used for the treatment of dyspepsia, hepatic ascites, tuberculosis, and various skin diseases including psoriasis. − Many abietane-related analogs have been isolated from the roots of E. fischeriana as the bioactive agents. − However, none of these compounds proved to be responsible for the antipsoriasis potential of E. fischeriana . As a part of our continuing pursuit to discover new antipsoriasis components targeting Kv1.3 ion channel from Euphorbia species, − the MeOH extract of aerial parts from E. fischeriana was recognized as the more active fraction.…”