Unraveling a role of molecular linker in nanoparticles self-organization by SERS spectroscopy: Comparative study of three aromatic diamines

Solovyeva, Elena V.; Смирнов, А Н; Svinko, Vasilisa O.; Strelnikov, Aleksei S.; Shevchuk, Alisa I.; Kazarian, Sergei G.

doi:10.1016/j.colsurfa.2022.128881

Cited by 3 publications

(1 citation statement)

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“…Colloidal nanoparticles tend to be absorbed by cells in the form of agglomerates. Such behavior can be beneficial in terms of the “hot spots” effect in situ as well as to intensify the localized photothermal therapy [ 44 , 45 ]. Based on the comparison of images taken in AsB (shows heavy elements predominantly) and InLens (shows all elements) modes, it can be concluded that the cell membrane covers the nanoparticles which locate inside the cell at different depths.…”

Section: Resultsmentioning

confidence: 99%

One-Pot Synthesis of Silica-Coated Gold Nanostructures Loaded with Cyanine 5.5 for Cell Imaging by SERS Spectroscopy

et al. 2023

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Anisotropic gold nanoparticles have been recognized as promising agents for medical diagnostics and cancer therapy due to their wide functionality, photothermal effect, and ability for optical signal amplification in the near-infrared range. In this work, a simple and rapid method for the preparation of bone-shaped gold nanoparticles coated with a dye-impregnated silica shell with an aminated surface is proposed. The possibility of further functionalization the nanostructures with a delivery vector using folic acid as an example is demonstrated. The average size of the resulting tags does not exceed 70 nm, meeting the criteria of cell endocytosis. The prepared tags exhibit surface-enhanced Raman scattering (SERS) spectra at excitation with lasers of 632.8 and 785 nm. Cell imaging is performed on HeLa cells based on the most pronounced SERS bands as a tracking signal. The obtained images, along with scanning electron microscopy of cell samples, revealed the tendency of tags to agglomerate during endocytosis followed by the “hot spots” effect. To evaluate the toxic and proliferative effect of the nanotags, an MTT assay was performed with two HeLa and HEP G2 cell lines. The results revealed higher viability for HEP G2 cells.

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Section: Resultsmentioning

confidence: 99%

One-Pot Synthesis of Silica-Coated Gold Nanostructures Loaded with Cyanine 5.5 for Cell Imaging by SERS Spectroscopy

et al. 2023

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Comparative study of fluorescence core-shell nanotags with different morphology of gold core

Svinko

Смирнов

Shevchuk

et al. 2023

Colloids and Surfaces B: Biointerfaces

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Surface-Enhanced Raman Scattering: 50 Years of Development and Its Role in Nanobiotechnology

Solovyeva

2024

Nanotechnol Russia

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The review covers the main stages in the development and achievements of surface-enhanced Raman scattering (SERS), the fiftieth anniversary of which we celebrate in 2024. Modern theoretical views on the SERS effect, a retrospective of the substrates and materials used, and expansion of the range of studied compounds and objects are presented. Using the example of the most important and interesting applications of SERS spectroscopy, the achievements of the last decade are considered; its role in modern surface chemistry, nanotechnology, bioanalysis and bioimaging methods is shown.

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Unraveling a role of molecular linker in nanoparticles self-organization by SERS spectroscopy: Comparative study of three aromatic diamines

Cited by 3 publications

References 55 publications

One-Pot Synthesis of Silica-Coated Gold Nanostructures Loaded with Cyanine 5.5 for Cell Imaging by SERS Spectroscopy

One-Pot Synthesis of Silica-Coated Gold Nanostructures Loaded with Cyanine 5.5 for Cell Imaging by SERS Spectroscopy

Comparative study of fluorescence core-shell nanotags with different morphology of gold core

Surface-Enhanced Raman Scattering: 50 Years of Development and Its Role in Nanobiotechnology

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