Unraveling devitalization: its impact on immune response and ectopic bone remodeling from autologous and allogeneic callus mimics
Leanne de Silva,
Jeroen J J P van den Beucken,
Antoine J W P Rosenberg
et al.
Abstract:Endochondral bone regeneration is a promising approach in regenerative medicine. Callus mimics (CMs) are engineered and remodeled into bone tissue upon implantation. The long-term objective is to fabricate a sustainable off-the-shelf treatment option for patients. Devitalization was introduced to facilitate storage and using allogeneic (donor) cells would further propel the off-the-shelf approach. However, allogeneic CMs for bone regeneration pose a potential antigenicity concern. Here, we explored the impact … Show more
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