2020
DOI: 10.1039/d0nr04526h
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Unraveling dominant surface physicochemistry to build antimicrobial peptide coatings with supramolecular amphiphiles

Abstract: With the increasing threat from antibiotic-resistant bacteria, surface modification with antimicrobial peptides (AMP) has been promisingly explored for preventing bacterial infections. Little is known on the critical factors that govern...

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Cited by 21 publications
(18 citation statements)
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“…The high stability of the GL13K coatings has been related to the ability of the peptides to self-assemble [ 49 , 52 ]. Moreover, recruitment of the AMPs to form the coatings was favored when the peptides interacted with highly polar, highly hydrophilic substrates [ 53 ]. This was attributed to the amphipathic nature of GL13K and their supramolecular structures.…”
Section: Discussionmentioning
confidence: 99%
“…The high stability of the GL13K coatings has been related to the ability of the peptides to self-assemble [ 49 , 52 ]. Moreover, recruitment of the AMPs to form the coatings was favored when the peptides interacted with highly polar, highly hydrophilic substrates [ 53 ]. This was attributed to the amphipathic nature of GL13K and their supramolecular structures.…”
Section: Discussionmentioning
confidence: 99%
“…Like most AMPs, GL13K peptide composition is rich in cationic and hydrophobic amino acids, including Ala, Ile, and Leu. 35 From SEM images, the supercial areas of SSG125 and SSG500 were visibly smaller than those in SLA samples; hence, both the amino acid sequence and the organic surface characteristics may contribute to the hydrophobicity of GL13K.…”
Section: Physicochemical Characterization Of Titanium Disk Coatingsmentioning
confidence: 96%
“…Hydrogen bonds are most suitable for this purpose. Prominent examples are the chains formed by molecules with two ureopyrimidine (upy) end groups [6], by bisureas with pendant hydrophobic groups [7][8], by small peptides in solvents of low polarity [9][10], by peptides with an alkyl 'tail' [11][12], or by folded polypeptides [13][14]. Also, coordination bonds can do the job, e.g., the combination of a bis-ligand with appropriate metal ions in water [15][16][17].…”
Section: Introductionmentioning
confidence: 99%