Unraveling dynamic interactions between tumor-associated macrophages and consensus molecular subtypes in colorectal cancer: An integrative analysis of single-cell and bulk RNA transcriptome

Gao, Han; Ma, Linyun; Zou, Qi; Hu, Bang; Cai, Keyu; Sun, Yi; Lu, Li; Ren, Donglin

doi:10.1016/j.heliyon.2023.e19224

Cited by 1 publication

(1 citation statement)

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“…Moreover, RGS19 is one of the most significant interaction partners of GIPC1, which is involved in the trafficking of transmembrane proteins and regulation of cellular processes involved in oncogenesis, including proliferation, planar cell polarity, cytokinesis and migration [ 92 ]. Importantly, RGS19 was identified as a gene related to a higher risk of worse survival in CRC patients [ 93 ].…”

Section: Rgs In Ibd Cac and Sporadic Crc Carcinogenesismentioning

confidence: 99%

Regulators of G-Protein Signaling (RGS) in Sporadic and Colitis-Associated Colorectal Cancer

Swierczynski,

Kasprzak,

Makaro

et al. 2024

IJMS

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Colorectal cancer (CRC) is one of the most common neoplasms worldwide. Among the risk factors of CRC, inflammatory bowel disease (IBD) is one of the most important ones leading to the development of colitis-associated CRC (CAC). G-protein coupled receptors (GPCR) are transmembrane receptors that orchestrate a multitude of signaling cascades in response to external stimuli. Because of their functionality, they are promising targets in research on new strategies for CRC diagnostics and treatment. Recently, regulators of G-proteins (RGS) have been attracting attention in the field of oncology. Typically, they serve as negative regulators of GPCR responses to both physiological stimuli and medications. RGS activity can lead to both beneficial and harmful effects depending on the nature of the stimulus. However, the atypical RGS—AXIN uses its RGS domain to antagonize key signaling pathways in CRC development through the stabilization of the β-catenin destruction complex. Since AXIN does not limit the efficiency of medications, it seems to be an even more promising pharmacological target in CRC treatment. In this review, we discuss the current state of knowledge on RGS significance in sporadic CRC and CAC with particular emphasis on the regulation of GPCR involved in IBD-related inflammation comprising opioid, cannabinoid and serotonin receptors.

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Section: Rgs In Ibd Cac and Sporadic Crc Carcinogenesismentioning

confidence: 99%