Unraveling fluctuation in gelatin and monovalent salt systems: coulombic starvation

Abstract

Fluctuations play a key role in biological systems. Here, fluctuations in gelatin intensify with increasing salt concentration. We find a redistribution of hydrogen bonds in protein-salt system due to unfulfilled...

Elucidating the influence of electrostatic force on the re-arrangement of H-bonds of protein polymers in the presence of salts

“…These unique properties make them crucial for application in a diverse range of fields, e.g., pharmaceuticals, biological systems, food processing, biomaterial design, etc. [1][2][3][4][5][6] These varieties of macroscopic attributes are directed by the microscopic properties of the polyampholytes, like their conformation, dynamics, morphology, etc. Thus, it is essential to understand the mechanism that determines the conformation of polyampholytes.…”

Electrostatic-Dominated Conformational Fluctuations and Transition States of Phase Separation in Charge-Balanced Protein Polymer

“…Salts alter the electrostatic forces by screening the charged interactions of the polymers. Salt addition to charged polymers also results in unfulfilled hydration of the polymer and salt-ions at higher concentrations . The hydration shell and bulk solvent fluctuations further control the polymer conformations. , These unsatisfied hydrations result in the polymer’s conformational fluctuation, dominated by the electrostatic forces, remaining in uncharted territory.…”