Unraveling lipid metabolism reprogramming for overcoming drug resistance in melanoma

Wang, Ruilong; Yan, Qin; Liu, Xiao; Wu, Jinfeng

doi:10.1016/j.bcp.2024.116122

Cited by 3 publications

(2 citation statements)

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“…Dysregulated lipid metabolism in cancer cells is a key factor contributing to drug resistance and malignant behavior in melanoma. Changes in the lipid metabolism of melanoma cells can alter the composition and physical properties of their cell membranes, potentially initiating or perpetuating treatment resistance [ 24 , 27 ]. In this section, we examine various signaling mechanisms that regulate lipid metabolism within the scope of skin cancer.…”

Section: Signaling Pathways and Target Proteins Associated With Lipid...mentioning

confidence: 99%

“…These changes support cell proliferation, survival, invasion, and metastasis [ 20 , 21 , 22 , 23 ]. Interestingly, it has been proposed that lipid metabolism is a significant hallmark in melanoma and inflammation-associated skin cancer [ 24 , 25 , 26 ]. Nonetheless, the investigation of the link between lipid metabolism and skin cancer remains nascent, underscoring the necessity for more thorough research.…”

Section: Introductionmentioning

confidence: 99%

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Elucidating the Role of Lipid-Metabolism-Related Signal Transduction and Inhibitors in Skin Cancer

Kook,

Kim

2024

Metabolites

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Lipids, as multifunctional molecules, play a crucial role in a variety of cellular processes. These include regulating membrane glycoprotein functions, controlling membrane trafficking, influencing apoptotic pathways, and affecting drug transport. In addition, lipid metabolites can alter the surrounding microenvironment in ways that might encourage tumor progression. The reprogramming of lipid metabolism is pivotal in promoting tumorigenesis and cancer progression, with tumors often displaying significant changes in lipid profiles. This review concentrates on the essential factors that drive lipid metabolic reprogramming, which contributes to the advancement and drug resistance in melanoma. Moreover, we discuss recent advances and current therapeutic strategies that employ small-molecule inhibitors to target lipid metabolism in skin cancers, particularly those associated with inflammation and melanoma.

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Section: Signaling Pathways and Target Proteins Associated With Lipid...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Elucidating the Role of Lipid-Metabolism-Related Signal Transduction and Inhibitors in Skin Cancer

Kook,

Kim

2024

Metabolites

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Melanoma Metabolism: Molecular Mechanisms and Therapeutic Implications in Cutaneous Oncology

Tan,

Parikh,

Cohen

2024

Cancer Medicine

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BackgroundMelanoma, a highly aggressive skin cancer, is characterized by rapid progression and a high metastatic potential, presenting significant challenges in clinical oncology. A critical aspect of melanoma biology is its metabolic reprogramming, which supports tumor growth, survival, and therapeutic resistance.ObjectiveThis review aims to explore the key molecular mechanisms driving metabolic alterations in melanoma and their implications for developing therapeutic strategies.MethodsA Pubmed search was conducted to analyze literature discussing key mechanisms of the Warburg effect, mitochondrial dysfunction, enhanced lipid metabolism, epigenetic modifications, and the tumor microenvironment.ResultsMetabolic reprogramming supports melanoma growth, proliferation, and survival. Understanding these complex metabolic dynamics provides valuable insights for developing targeted therapeutic strategies.ConclusionPotential therapeutic interventions aimed at disrupting melanoma metabolism highlight the promise of precision medicine in improving treatment outcomes in cutaneous oncology. By targeting metabolic vulnerabilities, novel treatment approaches could significantly enhance the clinical management and prognosis of melanoma.

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Preparation of poly(vinyl alcohol) nanofibers containing disulfiram-copper complex by electrospinning: a potential delivery system against melanoma

El Fawal,

Abu-Serie

2024

DARU J Pharm Sci

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Unraveling lipid metabolism reprogramming for overcoming drug resistance in melanoma

Cited by 3 publications

References 116 publications

Elucidating the Role of Lipid-Metabolism-Related Signal Transduction and Inhibitors in Skin Cancer

Elucidating the Role of Lipid-Metabolism-Related Signal Transduction and Inhibitors in Skin Cancer

Melanoma Metabolism: Molecular Mechanisms and Therapeutic Implications in Cutaneous Oncology

Preparation of poly(vinyl alcohol) nanofibers containing disulfiram-copper complex by electrospinning: a potential delivery system against melanoma

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