Unraveling molecular networks in thymic epithelial tumors: deciphering the unique signatures

Abstract

Thymic epithelial tumors (TETs) are a rare and diverse group of neoplasms characterized by distinct molecular signatures. This review delves into the complex molecular networks of TETs, highlighting key aspects such as chromosomal abnormalities, molecular subtypes, aberrant gene mutations and expressions, structural gene rearrangements, and epigenetic changes. Additionally, the influence of the dynamic tumor microenvironment on TET behavior and therapeutic responses is examined. A thorough understanding of these facets elucidates TET pathogenesis, offering avenues for enhancing diagnostic accuracy, refining prognostic assessments, and tailoring targeted therapeutic strategies. Our review underscores the importance of deciphering TETs’ unique molecular signatures to advance personalized treatment paradigms and improve patient outcomes. We also discuss future research directions and anticipated challenges in this intriguing field.

Anoikis resistance regulates immune infiltration and drug sensitivity in clear-cell renal cell carcinoma: insights from multi omics, single cell analysis and in vitro experiment

“…Additionally, the influence of L1CAM on the prognosis of endometrial cancer has been associated with its role in promoting Treg infiltration, thus impairing resistance to apoptosis ( 16 ). While existing research has elucidated the link between immune cell apoptosis and the prognosis of various cancers ( 17 , 18 ), tumor cells can evade immune detection by acquiring resistance to anoikis ( 19 ). Although clinical treatments for kidney cancer include radical surgical interventions, chemotherapy and immunotherapy, there is still a lack of recognized and reliable standard predictors for the diagnosis and prognosis of early-stage kidney cancer.…”

Image_2.tif

“…Additionally, the influence of L1CAM on the prognosis of endometrial cancer has been associated with its role in promoting Treg infiltration, thus impairing resistance to apoptosis (16). While existing research has elucidated the link between immune cell apoptosis and the prognosis of various cancers (17,18), tumor cells can evade immune detection by acquiring resistance to anoikis (19). Although clinical treatments for kidney cancer include radical surgical interventions, chemotherapy and immunotherapy, there is still a lack of recognized and reliable standard predictors for the diagnosis and prognosis of early-stage kidney cancer.…”

Image_1.tif

“…Additionally, the influence of L1CAM on the prognosis of endometrial cancer has been associated with its role in promoting Treg infiltration, thus impairing resistance to apoptosis (16). While existing research has elucidated the link between immune cell apoptosis and the prognosis of various cancers (17,18), tumor cells can evade immune detection by acquiring resistance to anoikis (19). Although clinical treatments for kidney cancer include radical surgical interventions, chemotherapy and immunotherapy, there is still a lack of recognized and reliable standard predictors for the diagnosis and prognosis of early-stage kidney cancer.…”