Unraveling molecular signatures in rare bone tumors and navigating the cancer pathway landscapes for targeted therapeutics

Wani, Atif Khurshid; Prakash, Ajit; Sena, Saikat; Akhtar, Nahid; Singh, Reena; Chopra, Chirag; Ariyanti, Esti Endah; Mudiana, Deden; Yulia, Nina Dwi; Rahayu, Farida

doi:10.1016/j.critrevonc.2024.104291

Cited by 4 publications

(1 citation statement)

References 223 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Relevant studies on mouse bone structure have shown that inhibiting the Wnt/b-catenin signaling pathway and activating the RANK signal promote bone resorption. Simultaneously, it has been demonstrated that Chemerin participates in the progression of bone tumors (151,183). However, the role of Chemerin in cancer remains contentious, with a majority of studies highlighting its anticancer effects, while a minority suggest its protumorigenic capabilities.…”

Section: Chemerinmentioning

confidence: 99%

Bone marrow adipocytes and lung cancer bone metastasis: unraveling the role of adipokines in the tumor microenvironment

Li,

Wu,

Xie

et al. 2024

Front. Oncol.

View full text Add to dashboard Cite

Bone is a common site of metastasis for lung cancer. The “seed and soil” hypothesis suggests that the bone marrow microenvironment (“soil”) may provide a conducive survival environment for metastasizing tumor cells (“seeds”). The bone marrow microenvironment, comprising a complex array of cells, includes bone marrow adipocytes (BMAs), which constitute about 70% of the adult bone marrow volume and may play a significant role in tumor bone metastasis. BMAs can directly provide energy for tumor cells, promoting their proliferation and migration. Furthermore, BMAs participate in the tumor microenvironment’s osteogenesis regulation, osteoclast(OC) regulation, and immune response through the secretion of adipokines, cytokines, and inflammatory factors. However, the precise mechanisms of BMAs in lung cancer bone metastasis remain largely unclear. This review primarily explores the role of BMAs and their secreted adipokines (leptin, adiponectin, Nesfatin-1, Resistin, chemerin, visfatin) in lung cancer bone metastasis, aiming to provide new insights into the mechanisms and clinical treatment of lung cancer bone metastasis.

show abstract

Section: Chemerinmentioning

confidence: 99%