Unraveling rapid extraction of fucoxanthin from Padina tetrastromatica: Purification, characterization and biomedical application

Raguraman, Vasantharaja; Abraham, L. Stanley; MubarakAli, D.; Narendrakumar, G.; Ramanathan, T.; Kirubagaran, R.; Thajuddin, Nooruddin

doi:10.1016/j.procbio.2018.08.006

Cited by 69 publications

(33 citation statements)

References 34 publications

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“…The optimized values for solvent concentration, temperature and time were EtOH 80%, 50 • C, and 30 min, respectively. These conditions allowed 750 µg/g DW of fucoxanthin to be obtained, which was higher than the fucoxanthin content obtained with conventional extraction [20].…”

Section: Ultrasound-assisted Extraction (Uea)mentioning

confidence: 71%

“…Finally, P. tetrastromatica has been extracted by using ME and UAE. Both techniques extracted a similar content of fucoxanthin, specifically, 0.41 and 0.75 mg/g DW [20,44].…”

Section: Comparison Of Extraction Systemsmentioning

confidence: 93%

“…Nevertheless, the commercialization and production of this compound still have to face certain challenges, since its chemical synthesis is a complex and inefficient process, and the method of extraction from marine organisms has not been yet standardized [18,19]. To achieve the profitably of a product, it should be easily and quickly obtained, using low-cost technologies [20]. Although fucoxanthin and other carotenoids may be artificially synthesized, their extraction from natural sources presents several advantages, such as easy accessibility to the sources and an economic and environmentally friendly production, avoiding the use of dangerous chemical compounds.…”

Section: Introductionmentioning

confidence: 99%

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Scientific Approaches on Extraction, Purification and Stability for the Commercialization of Fucoxanthin Recovered from Brown Algae

Lourenço-Lopes

García-Oliveira

Carpena

et al. 2020

Foods

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The scientific community has corroborated the numerous beneficial activities of fucoxanthin, such as its antioxidant, anti-inflammatory, anticancer or neuroprotective effects, among others. These properties have attracted the attention of nutraceutical, cosmetic and pharmacological industries, giving rise to various possible applications. Fucoxanthin may be chemically produced, but the extraction from natural sources is considered more cost-effective, efficient and eco-friendly. Thus, identifying suitable sources of this compound and giving a general overview of efficient extraction, quantification, purification and stabilization studies is of great importance for the future production and commercialization of fucoxanthin. The scientific research showed that most of the studies are performed using conventional techniques, but non-conventional techniques begin to gain popularity in the recovery of this compound. High Performance Liquid Chromatography (HPLC), Nuclear Magnetic Resonance (NMR) and spectroscopy techniques have been employed in the quantification and identification of fucoxanthin. The further purification of extracts has been mainly accomplished using purification columns. Finally, the stability of fucoxanthin has been assessed as a free molecule, in an emulsion, or encapsulated to identify the variables that might affect its further industrial application.

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Section: Ultrasound-assisted Extraction (Uea)mentioning

confidence: 71%

“…Finally, P. tetrastromatica has been extracted by using ME and UAE. Both techniques extracted a similar content of fucoxanthin, specifically, 0.41 and 0.75 mg/g DW [20,44].…”

Section: Comparison Of Extraction Systemsmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

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Scientific Approaches on Extraction, Purification and Stability for the Commercialization of Fucoxanthin Recovered from Brown Algae

Lourenço-Lopes

García-Oliveira

Carpena

et al. 2020

Foods

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“…To overcome the overheating issue, the sample is usually chilled in an ice bath prior to the ultrasonic treatment. In general, UAE with an ultrasound probe gave a higher yield of fucoxanthin (15.96 mg/g), as compared to the ultrasound bath yielding only 0.75-0.97 mg/g of extracted fucoxanthin (Kim et al, 2012;Papadaki et al, 2017;Raguraman et al, 2018). To date, there is still insufficient literature reporting the application of UAE of fucoxanthin from diatom species.…”

Section: Ultrasound-assisted Extraction (Uae)mentioning

confidence: 99%

Meeting Sustainable Development Goals: Alternative Extraction Processes for Fucoxanthin in Algae

Foo

Khoo

Ooi

et al. 2021

Front. Bioeng. Biotechnol.

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The ever-expanding human population puts tremendous pressure on global food security. With climate change threats lowering crop productivity and food nutritional quality, it is important to search for alternative and sustainable food sources. Microalgae are a promising carbon-neutral biomass with fast growth rate and do not compete with terrestrial crops for land use. More so, microalgae synthesize exclusive marine carotenoids shown to not only exert antioxidant activities but also anti-cancer properties. Unfortunately, the conventional method for fucoxanthin extraction is mainly based on solvent extraction, which is cheap but less environmentally friendly. With the emergence of greener extraction techniques, the extraction of fucoxanthin could adopt these strategies aligned to UN Sustainable Development Goals (SDGs). This is a timely review with a focus on existing fucoxanthin extraction processes, complemented with future outlook on the potential and limitations in alternative fucoxanthin extraction technologies. This review will serve as an important guide to the sustainable and environmentally friendly extraction of fucoxanthin and other carotenoids including but not limited to astaxanthin, lutein or zeaxanthin. This is aligned to the SDGs wherein it is envisaged that this review becomes an antecedent to further research work in extract standardization with the goal of meeting quality control and quality assurance benchmarks for future commercialization purposes.

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“…Given the actual interest in identifying antimicrobial compounds from algae, it is essential to achieve profitable and sustainable recovery of these compounds, in an easy and fast process [ 28 ]. Sometimes these compounds could be synthesized chemically, however, regarding the availability of algae, their recovery using green extraction technologies is an economic and environmentally friendly alternative that also avoids the use of dangerous chemical compounds.…”

Section: Introductionmentioning

confidence: 99%

Macroalgae as a Source of Valuable Antimicrobial Compounds: Extraction and Applications

et al. 2020

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In the last few decades, attention on new natural antimicrobial compounds has arisen due to a change in consumer preferences and the increase in the number of resistant microorganisms. Macroalgae play a special role in the pursuit of new active molecules as they have been traditionally consumed and are known for their chemical and nutritional composition and their biological properties, including antimicrobial activity. Among the bioactive molecules of algae, proteins and peptides, polysaccharides, polyphenols, polyunsaturated fatty acids and pigments can be highlighted. However, for the complete obtaining and incorporation of these molecules, it is essential to achieve easy, profitable and sustainable recovery of these compounds. For this purpose, novel liquid–liquid and solid–liquid extraction techniques have been studied, such as supercritical, ultrasound, microwave, enzymatic, high pressure, accelerated solvent and intensity pulsed electric fields extraction techniques. Moreover, different applications have been proposed for these compounds, such as preservatives in the food or cosmetic industries, as antibiotics in the pharmaceutical industry, as antibiofilm, antifouling, coating in active packaging, prebiotics or in nanoparticles. This review presents the main antimicrobial potential of macroalgae, their specific bioactive compounds and novel green extraction technologies to efficiently extract them, with emphasis on the antibacterial and antifungal data and their applications.

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Unraveling rapid extraction of fucoxanthin from Padina tetrastromatica: Purification, characterization and biomedical application

Cited by 69 publications

References 34 publications

Scientific Approaches on Extraction, Purification and Stability for the Commercialization of Fucoxanthin Recovered from Brown Algae

Scientific Approaches on Extraction, Purification and Stability for the Commercialization of Fucoxanthin Recovered from Brown Algae

Meeting Sustainable Development Goals: Alternative Extraction Processes for Fucoxanthin in Algae

Macroalgae as a Source of Valuable Antimicrobial Compounds: Extraction and Applications

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