Unraveling T cell exhaustion in the immune microenvironment of osteosarcoma via single-cell RNA transcriptome

Cheng, Debin; Zhang, Zhao; Liu, Dong; Mi, Zhenzhou; Tao, Weidong; Fu, Jun; Fan, Hongbin

doi:10.1007/s00262-023-03585-2

Cited by 2 publications

(1 citation statement)

References 42 publications

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“…Using single-cell sequencing technology, another observational study revealed that exhausted T cells exhibited substantial infiltration and a progressive increase in expression of CTLA4 in osteosarcoma samples. ( 31 ). An experimental study found that infection upregulates the inflammatory immune response mediated by canine macrophages, counteracting osteosarcoma-induced immune suppression through increasing CD80 expression ( 32 ).…”

Section: Discussionmentioning

confidence: 99%

Circulating immune cells and risk of osteosarcoma: a Mendelian randomization analysis

Li,

Sun,

Luo

et al. 2024

Front. Immunol.

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ObjectivesOsteosarcoma (OS) is the primary bone tumor originating from transformed mesenchymal cells. It is unclear whether associations between specific circulating immune cells and OS are causal or due to bias. To clarify whether predicted genetically altered circulating immune cells are associated with OS development, we performed a two-sample Mendelian randomization (MR) analysis.MethodsThe genetic variants strongly associated with immune cell traits as instrumental variables (IVs) were used to perform MR analyses. The effect of specific immune cells on OS risk was measured using the summary statistics from the genome-wide association studies (GWAS).ResultsOur findings indicate that CD80 on CD62L+ myeloid dendritic cell and CD28−CD4−CD8− T-cell absolute count are positively associated with OS (CD80 on CD62L+ myeloid dendritic cell, OR: 3.41 [95% CI: 1.40 to 8.31], p = 0.007; CD28−CD4−CD8− T-cell absolute count, OR: 4.49 [95% CI: 1.29 to 15.62], p = 0.018). It is also found that CD20 has a negative effect on CD24+CD27+ B cell on OS (OR: 0.32 [95% CI: 0.14 to 0.72], p = 0.006) and a similar impact on IgD+ CD38− B cell on OS (OR: 0.19 [95% CI: 0.05 to 0.68], p = 0.011).ConclusionsThese findings illustrate that the genetic predisposition to specific immune cells can exert a causal effect on OS risk, which confirms the crucial role played by immunity in OS development. Particularly, the causal association between immune cells and OS underscores the evidence for exploring the new treatment strategy for OS in the future.

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Section: Discussionmentioning

confidence: 99%

Circulating immune cells and risk of osteosarcoma: a Mendelian randomization analysis

Li,

Sun,

Luo

et al. 2024

Front. Immunol.

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Global research trends and hotspots in metabolomics of osteosarcoma: a decade-spanning bibliometric and visualized analysis

Tu,

Liu,

et al. 2024

Front. Immunol.

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ObjectOsteosarcoma is a malignant tumor originating from the bones, commonly found in children and adolescents, especially in rapidly growing bone areas such as the knees and upper arms. In this study, we aim to delineate the evolution and convergence of research themes in osteosarcoma metabolomics over the past decade, identify major contributors, and forecast emerging trends that could direct future research efforts.MethodThe bibliometric method has been applied to systematically analyze the literature in the field of osteosarcoma metabolomics. The relevant literatures were collected from the Web of Science Core Collection, spanning from January 1, 2014, to December 31, 2023. Tools such as CiteSpace, Bibliometrix, and VOSviewer were used for the visual analysis of the collected literatures. The focused information includes institutions, journals, countries, authors, keywords, and citations.ResultVarious aspects in the field of osteosarcoma metabolism were analyzed. Shanghai Jiao Tong University has published the most papers in the past ten years, followed by Central South University and Zhejiang University. Among the sources, the international journal of molecular sciences publishes the most articles, and oncotarget is the journal with the highest H index. According to Bradford’s law, there are 34 core journals identified. A total of 5501 authors participated in the creation of papers in this field. The distribution of authors follows Lotka`s Law, and 85.3% of authors have only one article. 46% of the corresponding authors are from China, but most of these corresponding authors are not good at international cooperation. China also has the largest number of publications, followed by the United States. It can be confirmed that China dominates this field. Among the keywords, “expression” is the keyword that has received the most attention in the past ten years. All keywords can be divided into 9 clusters. Based on the explosive words and hot topics each year, we speculate that future research will focus on the tumor microenvironment, molecular mechanisms and autophagy, targeted therapies and inhibitors.ConclusionIn summary, this study comprehensively analyzed the current state of research in the field of osteosarcoma metabolism through bibliometric methods. The findings revealed the development trends and research hotspots in this field, which may provide valuable references for future research directions.

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Unraveling T cell exhaustion in the immune microenvironment of osteosarcoma via single-cell RNA transcriptome

Cited by 2 publications

References 42 publications

Circulating immune cells and risk of osteosarcoma: a Mendelian randomization analysis

Circulating immune cells and risk of osteosarcoma: a Mendelian randomization analysis

Global research trends and hotspots in metabolomics of osteosarcoma: a decade-spanning bibliometric and visualized analysis

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