Unraveling the anti-virulence potential and antifungal efficacy of 5-aminotetrazoles using the zebrafish model of disseminated candidiasis

Radakovic, Natasa; Nikolić, Andrea; Jovanović, Nataša Terzić; Stojković, Pavle; Stanković, Nebojša; Šolaja, Bogdan A.; Opsenica, Igor; Pavić, Aleksandar

doi:10.1016/j.ejmech.2022.114137

Cited by 4 publications

(3 citation statements)

References 66 publications

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“…Among the tetrazoles, the 5‐amino derivatives show important applications as fuel in the production of grenades [7], energetic material used as propellant, explosives, and pyrotechnics [8], and ligands in coordination chemistry [9] and catalysis [10]. Additionally, the 5‐aminotetrazole core is of great significance in medicinal chemistry due to its wide range of pharmacological properties [11, 12]. A few examples of compounds bearing the 5‐aminotetrazole moiety are shown in Figure 1.…”

Section: Introductionmentioning

confidence: 99%

An eco‐friendly synthesis of 5‐aminotetrazoles using trichloroisocyanuric acid as desulfurization agent of thioureas

Moraes

Silva

Mattos

2023

Journal of Heterocyclic Chem

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A novel procedure for the preparation of various 5‐aminotetrazoles derivatives was achieved using trichloroisocyanuric acid as a desulfurizing agent of thioureas and trimethylsilyl azide in ethyl acetate at room temperature. This methodology provided substituted 5‐aminotetrazoles through a more sustainable reaction using an affordable, safe, stable, and easily handled N‐halo reagent, a safer azide source, and an environmentally friendly solvent.

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Section: Introductionmentioning

confidence: 99%

An eco‐friendly synthesis of 5‐aminotetrazoles using trichloroisocyanuric acid as desulfurization agent of thioureas

Moraes

Silva

Mattos

2023

Journal of Heterocyclic Chem

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“…Several studies have shown that the tetrazole moiety is required to enhance various organic molecules′ antifungal activity against pathogenic fungi. Aminotetrazole constructs inhibited 1,3‐β‐glucan synthase in some fungi [24] . Moreover, tetrazole derivatives are stable in metabolic processes that require many biochemical transformations to which carboxylic acid or amide functional groups are sensitive.…”

Section: Introductionmentioning

confidence: 99%

“…Aminotetrazole constructs inhibited 1,3-βglucan synthase in some fungi. [24] Moreover, tetrazole derivatives are stable in metabolic processes that require many biochemical transformations to which carboxylic acid or amide functional groups are sensitive. Because of these benefits, the tetrazole motif has been used in several FDA-approved drugs.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Properties of Azole Functional Silica Nanocomposites

Usul,

Lüleci,

Ergüden

et al. 2023

ChemistrySelect

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Silica nanoparticles have become more attractive due to their surface characteristics, versatility, biocompatibility, and morphological and physicochemical properties. For this reason, their use in biological applications has been expanding in recent years. In this study, after functionalizing silica nanoparticles with glycidyl methacrylate monomer, nanocomposites were formed by attaching 1,2,4‐Triazole, 3‐Amino‐1,2,4‐Triazole, and 5‐Aminotetrazole particles to the surface. Notably, the thermal degradation temperature of all nanocomposites was determined to surpass 200 °C. However, it is worth mentioning that despite the favorable water uptake rates observed for MT(7.64 %) and M3(5.98 %) nanocomposites, MT did not exhibit resistance against Fenton chemicals and experienced degradation. It is important to note that the material loss in M3 nanocomposites is minimal, measuring less than 1 %. In order to reveal the antifungal and antibacterial activity of the synthesized nanoparticles, Minimum inhibitory concentration(MIC), as well as Minimum Fungicidal Concentration(MFC) against the yeast strain Saccharomyces cerevisiae, and Minimum Bactericidal Concentration(MBC) values against bacteria strains, Staphylococcus aureus, Enterococcus faecalis and Escherichia coli were determined. The findings of the study indicated that MP, M3, and M5 nanocomposites displayed a moderate level of antibacterial activity. It is noteworthy, however, that the antibacterial activity diminished when triazole was combined with MP at concentrations exceeding 100 mg/mL.

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Maqui berry extract inhibits filamentation of Candidaalbicans and improves the antifungal efficacy of nystatin

Joncic Savic,

Djokic,

Stankovic

et al. 2023

Journal of Functional Foods

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Unraveling the anti-virulence potential and antifungal efficacy of 5-aminotetrazoles using the zebrafish model of disseminated candidiasis

Cited by 4 publications

References 66 publications

An eco‐friendly synthesis of 5‐aminotetrazoles using trichloroisocyanuric acid as desulfurization agent of thioureas

An eco‐friendly synthesis of 5‐aminotetrazoles using trichloroisocyanuric acid as desulfurization agent of thioureas

Antimicrobial Properties of Azole Functional Silica Nanocomposites

Maqui berry extract inhibits filamentation of Candidaalbicans and improves the antifungal efficacy of nystatin

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