Unraveling the ecotoxicity of deep eutectic solvents using the mixture toxicity theory

Macário, Inês P. E.; Jesus, Fátima; Pereira, Joana Luísa; Ventura, Sónia P. M.; Gonçalves, Ana M.M.; Coutinho, João A. P.; Gonçalves, Fernando

doi:10.1016/j.chemosphere.2018.08.153

Cited by 71 publications

(46 citation statements)

References 36 publications

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“…This result was consistent with other studies compared the toxicity of different ILs with DESs [125,126]. Macario et al [127] prepared 23 DESs using ethylene glycol and 1-propanol as HBDs; [N1111]Cl, [N2222]Cl, and [N3333]Cl as HBAs, at four different molar ratios 1:2, 1:1, 2:1, and 4:1. They reported that these DESs were not harmful to Aliivibrio fischeri, whereas they showed the toxicity in the following order: [N1111]Cl-based DES < [N2222]Cl-based DES < [N3333] Cl-based DES.…”

Section: Different Aspects Of the Utilization Of Deep Eutectic Solventssupporting

confidence: 91%

Use of Deep Eutectic Solvents in the Treatment of Agro-Industrial Lignocellulosic Wastes for Bioactive Compounds

Ünlü¹,

Takaç²

2021

Agroecosystems – Very Complex Environmental Systems

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Lignocellulose is the most abundant component in nature since it refers to plant material. Beyond the enormous utilization of lignocellulose by human being, unignorable amount of waste is also formed simultaneously. Agro-industrial lignocellulosic wastes can cause environmental pollutions if not processed before discharged. An innovative approach for lowering the detrimental influences of lignocellulosic wastes is to consider them as a source of useful products rather than a waste to be decontaminated. Beyond the conventional techniques for evaluation of the wastes, new emerging techniques and the use of new solvents have drawn attention recently. Among new generation solvents, deep eutectic solvents (DESs) have been increasingly used in the treatment of lignocellulosics to produce value-added products such as biofuels, chemicals, and solvents and also used for the recovery of bioactive phenolic compounds. DESs are used extensively for fractionation of lignocellulosic wastes, often in combination with enzymatic hydrolysis of the biomass. On the other hand, extraction and recovery of bioactive compounds are also under research using DESs. This mini review summarizes the very recent literature reports on the use of DESs in treating agro-industrial wastes within the concept of valorization of biomass.

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Section: Different Aspects Of the Utilization Of Deep Eutectic Solventssupporting

confidence: 91%

Use of Deep Eutectic Solvents in the Treatment of Agro-Industrial Lignocellulosic Wastes for Bioactive Compounds

Ünlü¹,

Takaç²

2021

Agroecosystems – Very Complex Environmental Systems

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“…This validated our measurement technique for the new system of TOPO andL-menthol. The toxicity of the extraction agents is of course important, and DESs are not necessarily less toxic than their constituents [58], although this will not be further examined in this work.…”

Section: Introductionmentioning

confidence: 99%

Hydrophobic Deep Eutectic Solvents for the Recovery of Bio-Based Chemicals: Solid–Liquid Equilibria and Liquid–Liquid Extraction

et al. 2021

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The solid–liquid equilibrium (SLE) behavior and liquid–liquid extraction (LLX) abilities of deep eutectic solvents (DESs) containing (a) thymol and L-menthol, and (b) trioctylphosphine oxide (TOPO) and L-menthol were evaluated. The distribution coefficients (KD) were determined for the solutes relevant for two biorefinery cases, including formic acid, levulinic acid, furfural, acetic acid, propionic acid, butyric acid, and L-lactic acid. Overall, for both cases, an increasing KD was observed for both DESs for acids increasing in size and thus hydrophobicity. Furfural, being the most hydrophobic, was seen to extract the highest KD (for DES (a) 14.2 ± 2.2 and (b) 4.1 ± 0.3), and the KD of lactic acid was small, independent of the DESs (DES (a) 0.5 ± 0.07 and DES (b) 0.4 ± 0.05). The KD of the acids for the TOPO and L-menthol DES were in similar ranges as for traditional TOPO-containing composite solvents, while for the thymol/L-menthol DES, in the absence of the Lewis base functionality, a smaller KD was observed. The selectivity of formic acid and levulinic acid separation was different for the two DESs investigated because of the acid–base interaction of the phosphine group. The thymol and L-menthol DES was selective towards levulinic acid (Sij = 9.3 ± 0.10, and the TOPO and L-menthol DES was selective towards FA (Sij = 2.1 ± 0.28).

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“…5 Cholinium chloride (ChCl) is one of the most recurring substances used to prepare DES and a large set of experimental solid-liquid equilibrium data on mixtures containing ChCl is already available in the literature, [7][8][9][10][11] with most of the DES prepared presenting low toxicity and being readily biodegradable. 12,13 Even though the deep eutectic solvent composed of urea and cholinium chloride was identified as a green solvent in 2003, 14 its structure and molecular interactions, along with macroscopic phenomena such as solid-liquid equilibria (SLE), still hold some mysteries. A recent study by van den Bruinhorst and co-workers 15 compares the currently available SLE data for the cholinium chloride/urea system, pointing out that the liquidus temperatures reported by Abbott and co-workers, 14 who measured freezing temperatures, are consistently lower than the melting temperatures reported by other authors 16,17 due to the phenomenon of supercooling, while Meng et al 16 attribute the observed discrepancies to the presence of water.…”

Section: Introductionmentioning

confidence: 99%

What a difference a methyl group makes – probing choline–urea molecular interactions through urea structure modification

Silva

Araújo

Abranches

et al. 2019

Phys. Chem. Chem. Phys.

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Unraveling the ecotoxicity of deep eutectic solvents using the mixture toxicity theory

Cited by 71 publications

References 36 publications

Use of Deep Eutectic Solvents in the Treatment of Agro-Industrial Lignocellulosic Wastes for Bioactive Compounds

Use of Deep Eutectic Solvents in the Treatment of Agro-Industrial Lignocellulosic Wastes for Bioactive Compounds

Hydrophobic Deep Eutectic Solvents for the Recovery of Bio-Based Chemicals: Solid–Liquid Equilibria and Liquid–Liquid Extraction

What a difference a methyl group makes – probing choline–urea molecular interactions through urea structure modification

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