Unraveling the etiology of ovarian cancer racial disparity in the deep south: Is it nature or nurture?

Ross, Jerlinda; Braswell, Katelyn V.; Silva, Luciana Madeira da; Mujica, Frances Currin; Stutsman, Sam; Finan, Michael A.; Nicolson, William; Harmon, Mary Danner; Missanelli, Megan; Cohen, Alex; Singh, Ajay P.; Scalici, Jennifer; Rocconi, Rodney P.

doi:10.1016/j.ygyno.2017.02.025

Cited by 28 publications

(20 citation statements)

References 17 publications

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“…Although it has been known for over a decade that there are racial disparities in EOC survival, few detailed analyses of differences that impact outcomes between groups exist. Our data support findings by Ross et al, who similarly found that black women in the Deep South have lower rates of optimal cytoreduction and IP chemotherapy, with poorer outcomes even after accounting for socioeconomic status [7]. In an analysis of the National Cancer Data Base, Bristow et al demonstrated that black race was independently associated with NCCN guideline non-adherence and worse overall survival [8].…”

Section: Discussionsupporting

confidence: 89%

Do differences in medical comorbidities and treatment impact racial disparities in epithelial ovarian cancer?

Dilley

Erickson

Phillips

et al. 2018

Gynecologic Oncology

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Section: Discussionsupporting

confidence: 89%

Do differences in medical comorbidities and treatment impact racial disparities in epithelial ovarian cancer?

Dilley

Erickson

Phillips

et al. 2018

Gynecologic Oncology

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“…Unfortunately, the OC health disparity has increased over time and one reason for this increase is the disparate access to treatment, particularly surgery [ 20 ]. In a study that evaluated 393 OC patients (68 AA vs. 325 CA), a clear survival disadvantage was observed in AA patients [ 21 ]. The AA patients had lower SES, in terms of education, income and property, to start with.…”

Section: Socioeconomic and Other Factors Contributing To Racial Healtmentioning

confidence: 99%

“…In fact, enhanced incidence and mortality in AA women with OC has been observed, as compared to EA counterparts, even when socioeconomic factors have been accounted for. For example, in a study that evaluated 393 OC patients (68 AA vs. 325 CA), a clear survival disadvantage was observed in AA patients [ 21 ]. The AA patients had lower SES, in terms of education, income and property, to start with.…”

Section: Biological Basis Of Ovarian Cancer Health Disparitiesmentioning

confidence: 99%

Racial health disparities in ovarian cancer: not just black and white

et al. 2017

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Ovarian cancer (OC) is the most lethal gynecological malignancy, which disproportionately affects African American (AA) women. Lack of awareness and socioeconomic factors are considered important players in OC racial health disparity, while at the same time, some recent studies have brought focus on the genetic basis of disparity as well. Differential polymorphisms, mutations and expressions of genes have been reported in OC patients of diverse racial and ethnic backgrounds. Combined, it appears that neither genetic nor the socioeconomic factors alone might explain the observed racially disparate health outcomes among OC patients. Rather, a more logical explanation would be the one that takes into consideration the combination and/or the interplay of these factors, perhaps even including some environmental ones. Hence, in this article, we attempt to review the available information on OC racial health disparity, and provide an overview of socioeconomic, environmental and genetic factors, as well as the epigenetic changes that can act as a liaison between the three. A better understanding of these underlying causes will help further research on effective cancer management among diverse patient population and ultimately narrow health disparity gaps.

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“…This result provides a window into potential disparities in our patients and is consistent with a previous study in Southern Alabama where NHB patients had lower rates of optimal debulking. 15 Multiple prior studies have shown that NHB race is associated with inequity in treatment, including delays in chemotherapy initiation and decreased rates of surgical staging. 3,6,7,16,17 Recently, Dilley et al showed that NHB race was also associated with higher medical comorbidities and lower rates of optimal cytoreduction.…”

Section: Discussionmentioning

confidence: 99%

Disparities in ovarian cancer survival at the only NCI-designated cancer center in Kansas

Petersen

Shahiri

Jewell

et al. 2021

The American Journal of Surgery

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Background: This study examined the impact of geographic distance on survival outcomes for patients receiving treatment for ovarian cancer at the only NCI-designated cancer center (NCI-CC) in Kansas. Methods: We identified ovarian cancer patients treated at the University of Kansas Cancer Center between 2010 and 2015. Demographic factors and clinical characteristics were abstracted. The main outcome measure was overall survival according to geographic distance from the institution. Kaplan Meier survival curves and Cox proportional hazard models were generated using SAS v9.4. Results: 220 patients were identified. Survival analysis based on distance from the institution demonstrated that patients who lived ≤10 miles from the institution had worse overall survival (p = 0.0207) and were more likely to have suboptimal cytoreductive surgery (p = 0.0276). Lower estimated median income was also associated with a 1.54 increased risk of death, 95% CI (1.031–2.292), p = 0.0347. Conclusions: We determined that ovarian cancer survival disparities exist in our patient population. Lower rates of optimal cytoreductive surgery has been identified as a possible driver of poor prognosis for patients who lived in proximity to our institution.

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Unraveling the etiology of ovarian cancer racial disparity in the deep south: Is it nature or nurture?

Cited by 28 publications

References 17 publications

Do differences in medical comorbidities and treatment impact racial disparities in epithelial ovarian cancer?

Do differences in medical comorbidities and treatment impact racial disparities in epithelial ovarian cancer?

Racial health disparities in ovarian cancer: not just black and white

Disparities in ovarian cancer survival at the only NCI-designated cancer center in Kansas

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