Unraveling the Genetic Interplay and Therapeutic Potentials between Major Depressive Disorder and Metabolic Syndrome: Multi-Ancestry and Multi-Trait Genome-Wide Association Analyses
Yu Feng,
Ningning Jia,
Xiaochu Gu
et al.
Abstract:This investigation elucidates the genetic connection between major depressive disorder (MD) and metabolic syndrome (MetS), uncovering bidirectional interactions and shared pleiotropic genes. Leveraging a comprehensive genome-wide association study (GWAS) dataset from European and East Asian populations, we discovered new genetic markers linked to MD and enhanced the robustness of genetic associations via cross-trait analysis. Moreover, the study harnessed computational strategies for drug repurposing, highligh… Show more
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