Unraveling the genetic mechanisms governing the host response to bovine anaplasmosis

Ahlawat, Sonika; Choudhary, Vikas; Kaur, Rashmeet; Arora, Reena; Sharma, Rekha; Chhabra, Pooja; Kumar, Ashish; Kaur, Mandeep

doi:10.1016/j.gene.2023.147532

Cited by 2 publications

(1 citation statement)

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“…Despite this, it was found that some functions of genes associated with resistance to other parasitic diseases, such as Amoebiasis, Trypanosomosis, Toxoplasmosis, and Leishmaniasis, are also common to candidate genes for resistance to Theileriosis and were identified in this study. Thus, we highlighted the action on the cell membrane (CMTM7, TMC2, and ATP12A genes), ATP binding (ATP12A gene), and immune response (MAP3K1, CMTM7, SSFA2, ATG13, and ZBTB44 genes) [70]. This work then made it possible to identify some SNPs suggestive of an association with resistance/tolerance to Tropical Theileriosis and the genes and QTLs that overlap or are in the vicinity.…”

Section: Discussionmentioning

confidence: 97%

A Genome-Wide Association Study for Resistance to Tropical Theileriosis in Two Bovine Portuguese Autochthonous Breeds

Valente,

Serra,

Carolino

et al. 2024

Pathogens

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The control of Tropical Theileriosis, a tick-borne disease with a strong impact on cattle breeding, can be facilitated using marker-assisted selection in breeding programs. Genome-wide association studies (GWAS) using high-density arrays are extremely important for the ongoing process of identifying genomic variants associated with resistance to Theileria annulata infection. In this work, single-nucleotide polymorphisms (SNPs) were analyzed in the Portuguese autochthonous cattle breeds Alentejana and Mertolenga. In total, 24 SNPs suggestive of significance (p ≤ 10−4) were identified for Alentejana cattle and 20 SNPs were identified for Mertolenga cattle. The genomic regions around these SNPs were further investigated for annotated genes and quantitative trait loci (QTLs) previously described by other authors. Regarding the Alentejana breed, the MAP3K1, CMTM7, SSFA2, and ATG13 genes are located near suggestive SNPs and appear as candidate genes for resistance to Tropical Theileriosis, considering its action in the immune response and resistance to other diseases. On the other hand, in the Mertolenga breed, the UOX gene is also a candidate gene due to its apparent link to the pathogenesis of the disease. These results may represent a first step toward the possibility of including genetic markers for resistance to Tropical Theileriosis in current breed selection programs.

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Section: Discussionmentioning

confidence: 97%