Unraveling the immunological roles of serum amyloid A3 in aortic immune cell subsets during atherosclerosis progression
Tzu-Yin Chou,
Yu-Zhen Ye,
I-Jung Lin
et al.
Abstract:Atherosclerosis is a growing concern in developed nations, necessitating the identification of therapeutic targets for advancing personalized medicine. Serum amyloid A3 (Saa3) has been linked to accelerated plaque progression by affecting cholesterol metabolism and modulation of inflammation. We hypothesize that knocking outSaa3(Saa3-/-) could mitigate plaque development by regulating aortic immune cell subsets during atherosclerosis progression. Using a murine model, we induced atherosclerosis via a gain-of-f… Show more
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