Unraveling the Interaction Mechanism of the Compounds From Cladophora sp to Recognize Prospective Larvicidal and Bactericidal Activities: In vitro and In Silico Approaches

Nachammai, K T.; Amaradeepa, S.; Raageshwari, S.; Swathilakshmi, A. V.; Poonkothai, M.; Langeswaran, K.

doi:10.1007/s12033-023-00902-z

Mol Biotechnol

2023

DOI: 10.1007/s12033-023-00902-z

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Unraveling the Interaction Mechanism of the Compounds From Cladophora sp to Recognize Prospective Larvicidal and Bactericidal Activities: In vitro and In Silico Approaches

K T. Nachammai,

S. Amaradeepa,

S. Raageshwari

et al.

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2024

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Cited by 1 publication

References 80 publications

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Antioxidant Valorization of PLE Extracts from Macroalgae (Cladophora glomerata): In Vitro Assessment of Nanoemulsions Against Oxidative Stress

Sáez-González,

Carreño-Díaz,

Blázquez-Abellán

et al. 2024

Antioxidants

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Driven by a growing global interest in natural products, macroalgae have emerged as a prime source for nutraceuticals and pharmaceutical applications. In the current research, the effect of oven-drying (OD) and freeze-drying (FD), as well as the pressurized liquid extraction (PLE) conditions, were investigated in relation to the polyphenols, flavonoids, carotenoids, chlorophylls, and tocochromanols levels in Cladophora glomerata extracts. The ethanol–water extracts (1:1) obtained with PLE-150 °C from macroalgae oven-dried (OD)-80 °C displayed the highest total polyphenol content (TPC) and total flavonoid contents (TFCs), reaching 29.62 mg GAE/g and 5.92 mg QE/g. Aqueous extracts using PLE-200 °C were also an excellent environmentally friendly option for TPC and TFC isolation, which were the main factors accounting for the ABTS, DPPH, and FRAP antioxidant activity of the extracts. The remarkable effects of drying conditions positively affect the carotenoids, chlorophyll α-tocopherol, and α-tocotrienol levels from extracts showing 1.3–6 times higher amounts in extracts of Cladophora glomerata OD at 80 °C compared with other research approaches. Nanotechnology approaches allowed the formulation of antioxidant-loaded nanoemulsions from Cladophora glomerata extracts, providing stability and a great internalization rate that ameliorates to 85% the ROS levels, attenuating the oxidative stress induced by H2O2 in J774.1 macrophage cell line.

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Antioxidant Valorization of PLE Extracts from Macroalgae (Cladophora glomerata): In Vitro Assessment of Nanoemulsions Against Oxidative Stress

Sáez-González,

Carreño-Díaz,

Blázquez-Abellán

et al. 2024

Antioxidants

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show abstract

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Unraveling the Interaction Mechanism of the Compounds From Cladophora sp to Recognize Prospective Larvicidal and Bactericidal Activities: In vitro and In Silico Approaches

Cited by 1 publication

References 80 publications

Antioxidant Valorization of PLE Extracts from Macroalgae (Cladophora glomerata): In Vitro Assessment of Nanoemulsions Against Oxidative Stress

Antioxidant Valorization of PLE Extracts from Macroalgae (Cladophora glomerata): In Vitro Assessment of Nanoemulsions Against Oxidative Stress

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