Unraveling the mechanism of alkaloids from Sophora alopecuroides Linn combined with immune checkpoint blockade in the treatment of non-small cell lung cancer based on systems pharmacology

Chen, Sen; Ma, Shuangxin; Wang, Haiqing; Shao, Xuexue; Ding, Bojiao; Guo, Zihu; Chen, Xuetong; Wang, Yonghua

doi:10.1016/j.bmc.2022.116724

Cited by 7 publications

(5 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on the literature, sophocarpine has been shown to have anticancer effects on lung cancer, colorectal cancer, cervical cancer, head and neck cancer, prostate cancer, myeloma and liver cancer. In a study exploring the efficiency of sophocarpine in treating non-small cell lung cancer (NSCLC), the authors used a systems pharmacology and bioinformatics approach, in combination with C57/BL6 mice and different cell lines, including human NSCLC cell lines (NCI-H1975 and A549) and mouse Lewis lung carcinoma cell lines, and found that the combination of sophocarpine and an anti-PD-L1 antibody significantly inhibited tumor growth via a mechanism involving the ADORA1-ATF3-PD-L1 axis ( Chen et al, 2022b ). To evaluate the antitumor effects of different alkaloids, Lin et al used human cancer cell lines of differing tissue origins.…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

A review on the pharmacology, pharmacokinetics and toxicity of sophocarpine

Wei,

Xiao,

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

Sophocarpine is a natural compound that belongs to the quinolizidine alkaloid family, and has a long history of use and widespread distribution in traditional Chinese herbal medicines such as Sophora alopecuroides L., Sophora flavescens Ait., and Sophora subprostrata. This article aims to summarize the pharmacology, pharmacokinetics, and toxicity of sophocarpine, evaluate its potential pharmacological effects in various diseases, and propose the necessity for further research and evaluation to promote its clinical application. A large number of studies have shown that it has anti-inflammatory, analgesic, antiviral, antiparasitic, anticancer, endocrine regulatory, and organ-protective effects as it modulates various signaling pathways, such as the NF-κB, MAPK, PI3K/AKT, and AMPK pathways. The distribution of sophocarpine in the body conforms to a two-compartment model, and sophocarpine can be detected in various tissues with a relatively short half-life. Although the pharmacological effects of sophocarpine have been confirmed, toxicity and safety assessments and reports on molecular mechanisms of its pharmacological actions have been limited. Given its significant pharmacological effects and potential clinical value, further research and evaluation are needed to promote the clinical application of sophocarpine.

show abstract

Section: Pharmacological Activitiesmentioning

confidence: 99%

A review on the pharmacology, pharmacokinetics and toxicity of sophocarpine

Wei,

Xiao,

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…Sophora alopecuroides Linn (SAL) is a Chinese herb with immunomodulating and anti-tumor functions ( 255 ). Sophocarpine (Sop) is one of the Alkaloids from SAL, and it can upregulate ADORA1 and ATF3 expression to increase the mRNA and protein level of PD-L1 ( 248 ).…”

Section: Natural Products Targeting Immune Checkpoints or Combined Wi...mentioning

confidence: 99%

“…Salvia miltiorrhiza Bunge (Danshen) extract cryptotanshinone, combined with anti-PD-L1 antibody, can make LLC-bearing mice tumor-free and increase CD45+ leukocytes, CD4+, and CD8+ T cells infiltration in tumors ( 292 , 298 ). Some natural products, such as Platycodon grandiflorum and Sophocarpine, have been reported to enhance the efficacy of anti-PD-L1 antibodies, suppressing tumor growth ( 248 , 265 ). Evodiamine has shown the ability to enhance the effectiveness of anti-PD-1 monoclonal antibodies (mAb), suppressing tumor growth and improving survival in LLC mice ( 194 ).…”

Section: Natural Products Targeting Immune Checkpoints or Combined Wi...mentioning

confidence: 99%

From immune checkpoints to therapies: understanding immune checkpoint regulation and the influence of natural products and traditional medicine on immune checkpoint and immunotherapy in lung cancer

Zhou,

Wang,

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

Lung cancer is a disease of global concern, and immunotherapy has brought lung cancer therapy to a new era. Besides promising effects in the clinical use of immune checkpoint inhibitors, immune-related adverse events (irAEs) and low response rates are problems unsolved. Natural products and traditional medicine with an immune-modulating nature have the property to influence immune checkpoint expression and can improve immunotherapy’s effect with relatively low toxicity. This review summarizes currently approved immunotherapy and the current mechanisms known to regulate immune checkpoint expression in lung cancer. It lists natural products and traditional medicine capable of influencing immune checkpoints or synergizing with immunotherapy in lung cancer, exploring both their effects and underlying mechanisms. Future research on immune checkpoint modulation and immunotherapy combination applying natural products and traditional medicine will be based on a deeper understanding of their mechanisms regulating immune checkpoints. Continued exploration of natural products and traditional medicine holds the potential to enhance the efficacy and reduce the adverse reactions of immunotherapy.

show abstract

“…Activated transcription factor 3 (ATF3) is abnormally expressed in a variety of cancers and is involved in tumorigenesis. By stimulating the ADORA1/ATF3 axis, sophocarpine increases PD-L1 expression, thereby enhancing the efficacy of PD-L1 inhibitory therapy ( 139 ).…”

Section: Anticancer Effects Of Natural Products When Targeting Tumor ...mentioning

confidence: 99%

A review of natural products targeting tumor immune microenvironments for the treatment of lung cancer

Yao,

Liang,

Liu

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

Lung cancer (LC) produces some of the most malignant tumors in the world, with high morbidity and mortality. Tumor immune microenvironment (TIME), a component of the tumor microenvironment (TME), are critical in tumor development, immune escape, and drug resistance. The TIME is composed of various immune cells, immune cytokines, etc, which are important biological characteristics and determinants of tumor progression and outcomes. In this paper, we reviewed the recently published literature and discussed the potential uses of natural products in regulating TIME. We observed that a total of 37 natural compounds have been reported to exert anti-cancer effects by targeting the TIME. In different classes of natural products, terpenoids are the most frequently mentioned compounds. TAMs are one of the most investigated immune cells about therapies with natural products in TIME, with 9 natural products acting through it. 17 natural products exhibit anti-cancer properties in LC by modulating PD-1 and PD-L1 protein activity. These natural products have been extensively evaluated in animal and cellular LC models, but their clinical trials in LC patients are lacking. Based on the current review, we have revealed that the mechanisms of LC can be treated with natural products through TIME intervention, resulting in a new perspective and potential therapeutic drugs.

show abstract

Unraveling the mechanism of alkaloids from Sophora alopecuroides Linn combined with immune checkpoint blockade in the treatment of non-small cell lung cancer based on systems pharmacology

Cited by 7 publications

References 52 publications

A review on the pharmacology, pharmacokinetics and toxicity of sophocarpine

A review on the pharmacology, pharmacokinetics and toxicity of sophocarpine

From immune checkpoints to therapies: understanding immune checkpoint regulation and the influence of natural products and traditional medicine on immune checkpoint and immunotherapy in lung cancer

A review of natural products targeting tumor immune microenvironments for the treatment of lung cancer

Contact Info

Product

Resources

About