Unraveling the Phenotypic Variability of Juvenile Idiopathic Arthritis across Races or Geographic Areas — Key to Understanding Etiology and Genetic Factors?

Consolaro, Alessandro; Ravelli, Angelo

doi:10.3899/jrheum.160173

Cited by 17 publications

(9 citation statements)

References 15 publications

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“…The second objective is to show cases of JIA and their characteristics in our region, and finally to evaluate the perception of parents and patients with JIA about the care received. The predominance of the polyarticular RF (-) form stands out in our cases, reported, to our knowledge, only in a cohort of Germany 13 , which contrasts with what has been published in other western countries, including national data, where the oligoarticular form predominates 3,4,5,[14][15][16] , and in Asian countries where systemic and enthesitis-related forms predominate 16,17 . The reasons for the predominance of the polyarticular form RF (-) are not clear, and although there was German colonization in this region, there is no history of patients with German ancestors in our cohort.…”

Section: Discussioncontrasting

confidence: 99%

Aporte del uso de herramientas básicas de Telemedicina en la atención de niños y adolescentes con Artritis idiopática juvenil, en el Hospital de Puerto Montt. Chile

Strickler¹,

Palma²,

Charris³

et al. 2018

Rev. chil. pediatr.

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Children and adolescents with rheumatologic diseases require specialized and comprehensive care, but pediatric rheumatologists and immunologists are concentrated in hospitals with specific, highcost and modern technology. Considering that some patients with juvenile idiopathic arthritis (JIA) live in rural, remote and limited accessibility areas, the use of Telemedicine (TM) can optimize diagnosis, follow-up and prognosis. Objective: Reporting 10 years of experience of a mixed care model: face-to-face and distance, using basic TM; the institutional impact, advantages, disadvantages and acceptance informed by parents and patients. Patients and Method: Exploratory, descriptive, and retrospective study with qualitative component. After the authorization of a scientific-ethics committee of the Reloncaví Health Service and the application of informed consent, a review of medical records was carried out and a qualitative survey was applied to parents and children over 14 years of age with JIA, seen between 2005-2015 in the pediatric ambulatory rheumatology polyclinic of Puerto Montt Hospital. Results: The were 27/35 participating patients with JIA attended by a trained pediatrician and assisted by distance (1,000 km) by an immunologist. The 8/35 patients did not answer by choice or change of address. The 70% of parents and patients accepted the model of care and 4% would prefer sporadic care only by specialists for diagnosis and follow-up. The number of patients transferred annually decreased from 10 to 1. The advantages of the care model outweighed the disadvantages perceived by parents and JIA patients. Conclusion: The use of TM tools in JIA decreased transfers, improved follow-up and were considered advantageous by patients and their parents. 60ORIGINAL ARTICLE Telemedicine -AS. Strickler et al

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Section: Discussioncontrasting

confidence: 99%

Aporte del uso de herramientas básicas de Telemedicina en la atención de niños y adolescentes con Artritis idiopática juvenil, en el Hospital de Puerto Montt. Chile

Strickler¹,

Palma²,

Charris³

et al. 2018

Rev. chil. pediatr.

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“…Broader insights into the worldwide variability of JIA phenotypes will come out of the multinational study of the EPidemiology, treatment and Outcome of Childhood Arthritis (EPOCA Study [5]), which has enrolled thus far around 9000 patients from 42 countries in five continents. The potential role of phenotypic variability of JIA across races or ethnic groups in explaining genetic predisposition and pathogenesis has been recently discussed [6]. …”

Section: Epidemiologymentioning

confidence: 99%

Juvenile Idiopathic Arthritis: Diagnosis and Treatment

et al. 2016

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Juvenile idiopathic arthritis is a broad term that describes a clinically heterogeneous group of arthritides of unknown cause, which begin before 16 years of age. This term encompasses several disease categories, each of which has distinct presentation, clinical manifestations, and, presumably, genetic background and etiopathogenesis. Although none of the available drugs has curative potential, prognosis has greatly improved as a result of substantial progresses in disease management. The most important new development has been the introduction of the biologic medications, which constitute a valuable treatment option for patients who are resistant to conventional antirheumatic agents. Further insights into the disease pathogenesis and treatment will be provided by the continuous advances in understanding of the mechanisms related to the immune response and inflammatory process, and by the development of new drugs that are capable of selectively inhibiting single molecules or pathways.

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“…The term juvenile idiopathic arthritis (JIA) embraces a heterogeneous group of disorders, all manifesting joint inflammation, but with different clinical phenotype, disease course, and outcomes as well as with distinct genetic background and pathophysiology 1 A number of epidemiologic studies have shown a marked disparity in the prevalence of JIA subsets among different geographic areas or racial/ethnic groups 3 . This variability may reflect diversity in genetic determinants and, perhaps, environmental triggers or etiopathologic pathways.…”

Section: Introductionmentioning

confidence: 99%

Phenotypic variability and disparities in treatment and outcomes of childhood arthritis throughout the world: an observational cohort study

Consolaro

Giancane

Alongi

et al. 2019

The Lancet Child & Adolescent Health

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145

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Unraveling the Phenotypic Variability of Juvenile Idiopathic Arthritis across Races or Geographic Areas — Key to Understanding Etiology and Genetic Factors?

Cited by 17 publications

References 15 publications

Aporte del uso de herramientas básicas de Telemedicina en la atención de niños y adolescentes con Artritis idiopática juvenil, en el Hospital de Puerto Montt. Chile

Aporte del uso de herramientas básicas de Telemedicina en la atención de niños y adolescentes con Artritis idiopática juvenil, en el Hospital de Puerto Montt. Chile

Juvenile Idiopathic Arthritis: Diagnosis and Treatment

Phenotypic variability and disparities in treatment and outcomes of childhood arthritis throughout the world: an observational cohort study

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