2024
DOI: 10.3389/fimmu.2024.1283364
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Unraveling the potential of CD8, CD68, and VISTA as diagnostic and prognostic markers in patients with pancreatic ductal adenocarcinoma

Fereshteh Rezagholizadeh,
Fatemeh Tajik,
Morteza Talebi
et al.

Abstract: IntroductionPancreatic cancer is a truculent disease with limited treatment options and a grim prognosis. Immunotherapy has shown promise in treating various types of cancer, but its effectiveness in pancreatic cancer has been lacking. As a result, it is crucial to identify markers associated with immunological pathways in order to improve the treatment outcomes for this deadly cancer. The purpose of this study was to investigate the diagnostic and prognostic significance of three markers, CD8, CD68, and VISTA… Show more

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Cited by 6 publications
(3 citation statements)
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“…VISTA is an immunological checkpoint protein, and its overexpression, together with increased levels of the VSIG3 and PSGL-1 receptors in the tumor microenvironment, may be involved in the modulation of immune responses to cancer. There is growing evidence of the importance of the immunosuppressive role of VISTA in cancer progression [ 20 , 41 , 57 , 62 , 63 , 69 73 ]. The presence of VISTA on the surface of cancer cells can not only modulate immune cells but also potentially play a much broader role in cancer biology.…”
Section: Discussionmentioning
confidence: 99%
“…VISTA is an immunological checkpoint protein, and its overexpression, together with increased levels of the VSIG3 and PSGL-1 receptors in the tumor microenvironment, may be involved in the modulation of immune responses to cancer. There is growing evidence of the importance of the immunosuppressive role of VISTA in cancer progression [ 20 , 41 , 57 , 62 , 63 , 69 73 ]. The presence of VISTA on the surface of cancer cells can not only modulate immune cells but also potentially play a much broader role in cancer biology.…”
Section: Discussionmentioning
confidence: 99%
“…Our study highlighted a pronounced inflammatory response in the vehicle group, evidenced by elevated markers like CD4, CD8a, and CD44. CD8a is a potential prognostic and diagnostic marker for inflammatory disorders and tumors, 48 , 49 used to predict severity in chronic rhinosinusitis and as a biomarker for rheumatoid arthritis. 50 CD8a expression is downregulated in a model of bronchopulmonary dysplasia.…”
Section: Discussionmentioning
confidence: 99%
“…In contrast to checkpoints that mainly control T-cell effector function and exhaustion, VISTA has various roles. It aids in the functioning of MDSCs, governs the activation of NK cells, promotes the survival of Tregs, restricts antigen presentation on APCs, and also maintains T cells in a state of rest [ 354 356 ]. The expression of VISTA is associated with a more favorable prognosis in cases of pancreatic cancer [ 357 ].…”
Section: Immunotherapeutic Approaches In Pancreatic Cancer Treatmentmentioning
confidence: 99%