Unraveling the rationale and conducting a comprehensive assessment of AdipoRon (adiponectin receptor agonist) as a candidate drug for diabetic nephropathy and cardiomyopathy prevention and intervention—a systematic review

Laurindo, Lucas Fornari; Laurindo, Lívia Fornari; Rodrigues, Victória Dogani; Catharin, Virgínia Maria Cavallari Strozze; Simili, Otávio Augusto Garcia; Barboza, Gabriella Oliveira; Catharin, Vitor Cavallari Strozze; Sloan, Kátia Portero; Barbalho, Sandra Maria

doi:10.1007/s00210-024-03362-7

Naunyn-Schmiedeberg's Arch Pharmacol

2024

DOI: 10.1007/s00210-024-03362-7

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Unraveling the rationale and conducting a comprehensive assessment of AdipoRon (adiponectin receptor agonist) as a candidate drug for diabetic nephropathy and cardiomyopathy prevention and intervention—a systematic review

Lucas Fornari Laurindo,

Lívia Fornari Laurindo,

Victória Dogani Rodrigues

et al.

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Cited by 3 publications

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Mechanisms and effects of AdipoRon, an adiponectin receptor agonist, on ovarian granulosa cells—a systematic review

Laurindo,

Rodrigues

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Mechanisms and effects of AdipoRon, an adiponectin receptor agonist, on ovarian granulosa cells—a systematic review

Laurindo,

Rodrigues

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Vascular Impairment, Muscle Atrophy, and Cognitive Decline: Critical Age-Related Conditions

de Lima,

Tanaka,

Lamas

et al. 2024

Biomedicines

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The triad of vascular impairment, muscle atrophy, and cognitive decline represents critical age-related conditions that significantly impact health. Vascular impairment disrupts blood flow, precipitating the muscle mass reduction seen in sarcopenia and the decline in neuronal function characteristic of neurodegeneration. Our limited understanding of the intricate relationships within this triad hinders accurate diagnosis and effective treatment strategies. This review analyzes the interrelated mechanisms that contribute to these conditions, with a specific focus on oxidative stress, chronic inflammation, and impaired nutrient delivery. The aim is to understand the common pathways involved and to suggest comprehensive therapeutic approaches. Vascular dysfunctions hinder the circulation of blood and the transportation of nutrients, resulting in sarcopenia characterized by muscle atrophy and weakness. Vascular dysfunction and sarcopenia have a negative impact on physical function and quality of life. Neurodegenerative diseases exhibit comparable pathophysiological mechanisms that affect cognitive and motor functions. Preventive and therapeutic approaches encompass lifestyle adjustments, addressing oxidative stress, inflammation, and integrated therapies that focus on improving vascular and muscular well-being. Better understanding of these links can refine therapeutic strategies and yield better patient outcomes. This study emphasizes the complex interplay between vascular dysfunction, muscle degeneration, and cognitive decline, highlighting the necessity for multidisciplinary treatment approaches. Advances in this domain promise improved diagnostic accuracy, more effective therapeutic options, and enhanced preventive measures, all contributing to a higher quality of life for the elderly population.

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Adipokines in the Crosstalk between Adipose Tissues and Other Organs: Implications in Cardiometabolic Diseases

Hemat Jouy,

Mohan,

Scichilone

et al. 2024

Biomedicines

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Adipose tissue was previously regarded as a dormant organ for lipid storage until the identification of adiponectin and leptin in the early 1990s. This revelation unveiled the dynamic endocrine function of adipose tissue, which has expanded further. Adipose tissue has emerged in recent decades as a multifunctional organ that plays a significant role in energy metabolism and homeostasis. Currently, it is evident that adipose tissue primarily performs its function by secreting a diverse array of signaling molecules known as adipokines. Apart from their pivotal function in energy expenditure and metabolism regulation, these adipokines exert significant influence over a multitude of biological processes, including but not limited to inflammation, thermoregulation, immune response, vascular function, and insulin sensitivity. Adipokines are pivotal in regulating numerous biological processes within adipose tissue and facilitating communication between adipose tissue and various organs, including the brain, gut, pancreas, endothelial cells, liver, muscle, and more. Dysregulated adipokines have been implicated in several metabolic diseases, like obesity and diabetes, as well as cardiovascular diseases. In this article, we attempted to describe the significance of adipokines in developing metabolic and cardiovascular diseases and highlight their role in the crosstalk between adipose tissues and other tissues and organs.

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Unraveling the rationale and conducting a comprehensive assessment of AdipoRon (adiponectin receptor agonist) as a candidate drug for diabetic nephropathy and cardiomyopathy prevention and intervention—a systematic review

Cited by 3 publications

References 50 publications

Mechanisms and effects of AdipoRon, an adiponectin receptor agonist, on ovarian granulosa cells—a systematic review

Mechanisms and effects of AdipoRon, an adiponectin receptor agonist, on ovarian granulosa cells—a systematic review

Vascular Impairment, Muscle Atrophy, and Cognitive Decline: Critical Age-Related Conditions

Adipokines in the Crosstalk between Adipose Tissues and Other Organs: Implications in Cardiometabolic Diseases

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