Unraveling the role of <i>LDHA</i> and <i>VEGFA</i> in oxidative stress: A pathway to therapeutic interventions in cerebral aneurysms
Jiaying Wu,
Lixia Lu,
Beibei Dai
et al.
Abstract:Cerebral aneurysms (CA) are critical conditions often associated with oxidative stress in vascular endothelial cells (VECs). The enzyme lactate dehydrogenase A (LDHA) plays a crucial role in glycolysis and lactate metabolism, processes implicated in the pathogenesis of aneurysms. Understanding these molecular mechanisms can inform the development of novel therapeutic targets. This study investigated the role of lactate metabolism and lactate-related genes, particularly LDHA and vascular endothelial growth fact… Show more
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