2024
DOI: 10.1093/jalm/jfae115
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Unraveling Uncertainty: The Impact of Biological and Analytical Variation on the Prediction Uncertainty of Categorical Prediction Models

Remy J H Martens,
William P T M van Doorn,
Mathie P G Leers
et al.

Abstract: Background Interest in prediction models, including machine learning (ML) models, based on laboratory data has increased tremendously. Uncertainty in laboratory measurements and predictions based on such data are inherently intertwined. This study developed a framework for assessing the impact of biological and analytical variation on the prediction uncertainty of categorical prediction models. Methods Practical application w… Show more

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