2013
DOI: 10.1038/nrc3597
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Unravelling cancer stem cell potential

Abstract: The maintenance and repair of many adult tissues are ensured by stem cells (SCs), which reside at the top of the cellular hierarchy of these tissues. Functional assays, such as in vitro clonogenic assays, transplantation and in vivo lineage tracing, have been used to assess the renewing and differentiation potential of normal SCs. Similar strategies have suggested that solid tumours may also be hierarchically organized and contain cancer SCs (CSCs) that sustain tumour growth and relapse after therapy. In this … Show more

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Cited by 744 publications
(668 citation statements)
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References 162 publications
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“…Since TIC cells are essential for tumor initiation, tumor maintenance, and tumor growth (Cheng & O'Neill, 2009; Ricci‐Vitiani et al , 2009; Grinshtein et al , 2011; Beck & Blanpain, 2013; Bansal et al , 2016; Zhang et al , 2016), increased TIC activity is expected to accelerate tumor growth in vivo (Grinshtein et al , 2011; Beck & Blanpain, 2013; Bansal et al , 2016). To test the effect of FUT9 on this process, we generated a xenograft model of colorectal cancer in immune‐deficient NOD/SCID gamma mice.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Since TIC cells are essential for tumor initiation, tumor maintenance, and tumor growth (Cheng & O'Neill, 2009; Ricci‐Vitiani et al , 2009; Grinshtein et al , 2011; Beck & Blanpain, 2013; Bansal et al , 2016; Zhang et al , 2016), increased TIC activity is expected to accelerate tumor growth in vivo (Grinshtein et al , 2011; Beck & Blanpain, 2013; Bansal et al , 2016). To test the effect of FUT9 on this process, we generated a xenograft model of colorectal cancer in immune‐deficient NOD/SCID gamma mice.…”
Section: Resultsmentioning
confidence: 99%
“…TICs represent a higher proportion of the overall cell population in a tumor at earlier stages of tumor development. At later stages however, TICs are gradually outgrown by the rest of the tumor cells (Fig 4E), but they are still required for efficient tumor growth and maintenance (Cheng & O'Neill, 2009; Ricci‐Vitiani et al , 2009; Grinshtein et al , 2011; Beck & Blanpain, 2013; Bansal et al , 2016; Zhang et al , 2016). Since our experimental data suggest that FUT9 provides an advantage for TIC populations, while its reduced activity benefits other tumor cells, its relative abundance should be expected to gradually drop with tumor progression, mirroring a decrease in the proportional representation of TICs.…”
Section: Discussionmentioning
confidence: 99%
“…The tumorigenic CSCs are responsible for driving tumour initiation, maintenance and recurrence, whereas the non-tumorigenic cells comprise the bulk of the tumour but cannot self-renew or initiate tumour formation. Thus, cancer stem cell hypothesis posits that the functional heterogeneity seen in cancer is due to differences in differentiation status, with CSCs at the top of the hierarchy, followed by progenitor cells and bulk of the tumour cells [4,5].…”
Section: Introductionmentioning
confidence: 99%
“…Our finding indicates an enrichment of cancer cells in the scrapings as the corresponding primary tumor area consisted of 75-80% cancer cells as assessed by hematoxylin-eosin staining of tissue sections (Figures 2c and d). 15 CSCs are phenotypically characterized by the cell-surface markers CD44 þ CD24 À , the functional marker ALDH1 High and the fluorescent marker PKH26, which labels quiescent cells. [16][17][18] Hence, high expression of CSC-phenotypic markers in vivo correlates with poor prognosis.…”
Section: Enrichment Of Breast Cancer Cells By Superficial Scrapingsmentioning
confidence: 99%