Unravelling the bioprospects of mycoendophytes residing in Withania somnifera for productive pharmaceutical applications

Varghese, Siby; Akshaya, C.S.; Jisha, M. S.

doi:10.1016/j.bcab.2021.102172

Cited by 7 publications

(2 citation statements)

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“…The chromatogram of the AREF023 extract showed a peak at Rt 9.71 with m / z 799.6769 and chemical formula C 15 H 11 I 4 NO 4 , which was identified as Levothyroxine sodium anhydrous. A steroidal saponin compound, which is a well-known plant secondary metabolite and anticancer pharmaceutical bioactive obtained from endophytic fungi, was tentatively identified [ 42 , 43 ]. The peak at retention time 9.26, having m / z 815.6778 matching the chemical formula C 51 H 90 O 7 , was identified as Sitoindoside I.…”

Section: Resultsmentioning

confidence: 99%

Bio-Synthesis of Aspergillus terreus Mediated Gold Nanoparticle: Antimicrobial, Antioxidant, Antifungal and In Vitro Cytotoxicity Studies

et al. 2022

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Gold nanoparticles (GNP) were bio-fabricated utilizing the methanolic extract of the endophytic isolate Aspergillus terreus. The biosynthesised gold nanoparticles (GNP023) were characterised using UV-visible spectroscopy (UV-Vis); transmission electron microscopy (TEM), Fourier-transform nfrared spectroscopy (FTIR) and X-ray diffraction (XRD) studies. The bio-fabricated GNP023 displayed a sharp SPR peak at 536 nm, were spherically shaped, and had an average size between 10–16 nm. The EDX profile confirmed the presence of gold (Au), and XRD analysis confirmed the crystalline nature of GNP023. The antimicrobial activity of GNP023 was investigated against several food-borne and phytopathogens, using in vitro antibacterial and antifungal assays. The maximum zone of inhibition was observed for S. aureus and V. cholera at 400 μg /mL, whereas inhibition in radial mycelial growth was observed against Fusarium oxysporum and Rhizoctonia solani at 52.5% and 65.46%, respectively, when challenged with GNP023 (200 μg/mL). Moreover, the gold nanoparticles displayed significant antioxidant activity against the ABTS radical, with an IC50 of 38.61 µg/mL, and were non-toxic when tested against human kidney embryonic 293 (HEK293) cells. Thus, the current work supports the application of myco-synthesised gold nanoparticles as a versatile antimicrobial candidate against food-borne pathogens.

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Section: Resultsmentioning

confidence: 99%

Bio-Synthesis of Aspergillus terreus Mediated Gold Nanoparticle: Antimicrobial, Antioxidant, Antifungal and In Vitro Cytotoxicity Studies

et al. 2022

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“…Withania somnifera (L.) Dunal, is a valuable medicinal herb with a range of therapeutic properties, widely used in Ayurvedic medicine. Abundant fungal endophytes have been isolated from different tissues of W. somnifera that were gathered from Kerala, Madhya Pradesh, Western Himalayas, and Pakistan [ 151 ]. Specific endophytes in association with W. somnifera can enhance the biosynthesis and accumulation of specific secondary metabolites [ 152 ].A group of 11 fungal strains capable of enhancing the growth and secondary metabolite production of W. Somnifera were isolated and identified [ 153 ].…”

Section: Exploring the Diversity Of Endophytic Fungi Residing In Medi...mentioning

confidence: 99%

Endophytic fungi: A future prospect for breast cancer therapeutics and drug development

Varghese,

Jisha,

Rajeshkumar

et al. 2024

Heliyon

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Withanolides production by the endophytic fungus Penicillium oxalicum associated with Withania somnifera (L.) Dunal

Gupta,

Vasundhara

2024

World J Microbiol Biotechnol

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Unravelling the bioprospects of mycoendophytes residing in Withania somnifera for productive pharmaceutical applications

Cited by 7 publications

References 95 publications

Bio-Synthesis of Aspergillus terreus Mediated Gold Nanoparticle: Antimicrobial, Antioxidant, Antifungal and In Vitro Cytotoxicity Studies

Bio-Synthesis of Aspergillus terreus Mediated Gold Nanoparticle: Antimicrobial, Antioxidant, Antifungal and In Vitro Cytotoxicity Studies

Endophytic fungi: A future prospect for breast cancer therapeutics and drug development

Withanolides production by the endophytic fungus Penicillium oxalicum associated with Withania somnifera (L.) Dunal

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