2024
DOI: 10.1021/acs.jcim.4c01479
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Unravelling the Complexity of Amyloid Peptide Core Interfaces

Máté Sulyok-Eiler,
Veronika Harmat,
András Perczel

Abstract: Amyloids, large intermolecular sandwiched β-sheet structures, underlie several protein misfolding diseases but have also been shown to have functional roles and can be a basis for designing smart and responsive nanomaterials. Short segments of proteins, called aggregation-prone regions (APRs), have been identified that nucleate amyloid formation. Here we present the database of 173 APR crystal structures currently available in the PDB, and a tool, ACW, for analyzing their topologies and the 267 inter-β-sheet i… Show more

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