Unravelling the genetic basis of schizophrenia and bipolar disorder with GWAS: A systematic review

Prata, Diana; Neves, B. Costa; Cosme, Gonçalo; Vassos, Evangelos

doi:10.1016/j.jpsychires.2019.04.007

Cited by 94 publications

(49 citation statements)

References 433 publications

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“…Notably, mir137 was found to be linked to schizophrenia in an early genome-wide association study (86), a finding that was confirmed in the largest genome-wide association study of schizophrenia existing to date (4). In further support of its involvement in schizophrenia, mir137 represents an important signaling node in various gene networks relevant to brain development and functions, including axon guidance signaling, ephrin receptor signaling, and synaptic activity (87,88), all of which are known to be disrupted in schizophrenia and related disorders (2)(3)(4)(5).…”

Section: Noncoding Rnasmentioning

confidence: 99%

“…The clinical heterogeneity of schizophrenia is also mirrored by the underlying genetic risk, which appears to be polygenic and highly heterogeneous. While both common and rare genetic variants shape the risk of developing schizophrenia (3,4), the disorder's common genetic risk is usually indexed by the PRS, which reflects the cumulative sum of risk-associated alleles at common variants across the entire genome (4).…”

Section: Epigenetic Modifications As Source Of Phenotypic Variabilitymentioning

confidence: 99%

“…The etiology of schizophrenia is likely to be multifactorial, with multiple small-effect and fewer large-effect susceptibility genes interacting with several environmental factors (2)(3)(4). The combination of genetic and environmental risk factors is believed to affect the normal course of brain development and maturation, manifesting in a cascade of neurotransmitter and circuit dysfunctions and impaired connectivity in early adulthood (5,6).…”

mentioning

confidence: 99%

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Epigenetic Modifications in Schizophrenia and Related Disorders: Molecular Scars of Environmental Exposures and Source of Phenotypic Variability

Richetto

Meyer

2021

Biological Psychiatry

122

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Epigenetic modifications are increasingly recognized to play a role in the etiology and pathophysiology of schizophrenia and other psychiatric disorders with developmental origins. Here, we summarize clinical and preclinical findings of epigenetic alterations in schizophrenia and relevant disease models and discuss their putative origin. Recent findings suggest that certain schizophrenia risk loci can influence stochastic variation in gene expression through epigenetic processes, highlighting the intricate interaction between genetic and epigenetic control of neurodevelopmental trajectories. In addition, a substantial portion of epigenetic alterations in schizophrenia and related disorders may be acquired through environmental factors and may be manifested as molecular "scars." Some of these scars can influence brain functions throughout the entire lifespan and may even be transmitted across generations via epigenetic germline inheritance. Epigenetic modifications, whether caused by genetic or environmental factors, are plausible molecular sources of phenotypic heterogeneity and offer a target for therapeutic interventions. The further elucidation of epigenetic modifications thus may increase our knowledge regarding schizophrenia's heterogeneous etiology and pathophysiology and, in the long term, may advance personalized treatments through the use of biomarker-guided epigenetic interventions.

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Section: Noncoding Rnasmentioning

confidence: 99%

Section: Epigenetic Modifications As Source Of Phenotypic Variabilitymentioning

confidence: 99%

mentioning

confidence: 99%

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Epigenetic Modifications in Schizophrenia and Related Disorders: Molecular Scars of Environmental Exposures and Source of Phenotypic Variability

Richetto

Meyer

2021

Biological Psychiatry

122

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“…These hypotheses might also apply to bipolar disorder, as GWAS research suggests the bipolar disorder and schizophrenia share an underlying genetic risk (Prata, Costa‐Neves, Cosme, & Vassos, ). Bipolar disorder, which usually onsets in late adolescence or early adulthood (Leboyer, Henry, Paillere‐Martinot, & Bellivier, ; Nowrouzi et al, ), is characterized by rapid shifts between symptoms of mania and depression (Merikangas et al, ).…”

Section: Developmental Disordersmentioning

confidence: 99%

Mental health is biological health: Why tackling “diseases of the mind” is an imperative for biological anthropology in the 21st century

Syme

Hagen

2019

American J Phys Anthropol

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The germ theory of disease and the attendant public health initiatives, including sanitation, vaccination, and antibiotic treatment, led to dramatic increases in global life expectancy. As the prevalence of infectious disease declines, mental disorders are emerging as major contributors to the global burden of disease. Scientists understand little about the etiology of mental disorders, however, and many of the most popular psychopharmacological treatments, such as antidepressants and antipsychotics, have only moderate-to-weak efficacy in treating symptoms and fail to target biological systems that correspond to discrete psychiatric syndromes. Consequently, despite dramatic increases in the treatment of some mental disorders, there has been no decrease in the prevalence of most mental disorders since accurate record keeping began. Many researchers and theorists are therefore endeavoring to rethink psychiatry from the ground-up. Anthropology, especially biological anthropology, can offer critical theoretical and empirical insights to combat mental illness globally. Biological anthropologists are unique in that we take a panhuman approach to human health and behavior and are trained to address each of Tinbergen's four levels of analysis as well as culture. The field is thus exceptionally well-situated to help resolve the mysteries of mental illness by integrating biological, evolutionary, and sociocultural perspectives. K E Y W O R D S evolutionary medicine, mental health, psychopathology

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“…Both schizophrenia and bipolar disorder are strongly influenced by genetics. However, singlenucleotide polymorphisms (SNP) explain only a small variance of the risk for the disorders (10)(11)(12). It is therefore of great interest to find endophenotypes, which are located between the genetic and the symptomatic levels, to identify risk factors and thus improve diagnosis (13,14).…”

Section: Introductionmentioning

confidence: 99%

Electrophysiological correlates of visual backward masking in patients with bipolar disorder

Garobbio

Roinishvili

Favrod

et al. 2020

Preprint

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Background:In visual backward masking (VBM), a target is followed by a mask that decreases target discriminability. Schizophrenia patients (SZ) show strong and reproducible masking impairments, which are associated with reduced EEG amplitudes. Patients with bipolar disorder (BP) show masking deficits, too. Here, we investigated the neural EEG correlates of VBM in BP.Methods: 122 SZ, 94 unaffected controls, and 38 BP joined a standard VBM experiment. 123 SZ, 94 unaffected controls and 16 BP joined a corresponding EEG experiment, analyzed in terms of the global field power. Results:As in previous studies, SZ and BP show strong masking deficits. Importantly and similarly to SZ, BP show decreased global field power amplitudes at approximately 200 ms after the target onset, compared to controls. Conclusions:These results suggest that VBM deficits are not specific for schizophrenia but for a broader range of functional psychoses. Potentially, both SZ and BP show deficient target enhancement.

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Unravelling the genetic basis of schizophrenia and bipolar disorder with GWAS: A systematic review

Cited by 94 publications

References 433 publications

Epigenetic Modifications in Schizophrenia and Related Disorders: Molecular Scars of Environmental Exposures and Source of Phenotypic Variability

Epigenetic Modifications in Schizophrenia and Related Disorders: Molecular Scars of Environmental Exposures and Source of Phenotypic Variability

Mental health is biological health: Why tackling “diseases of the mind” is an imperative for biological anthropology in the 21st century

Electrophysiological correlates of visual backward masking in patients with bipolar disorder

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