Unravelling the Gut Microbiota of Cow’s Milk–Allergic Infants, Their Mothers, and Their Grandmothers

Mera-Berriatua, L; Zubeldia-Varela, E; Martín-Antoniano, IA; Maturana, Evangelina López de; Rojo, D; Bazire, R; Cabrera-Freitag, P; Barker-Tejeda, TC; Ubeda, C; Barber, C; Francino, MP; Ibáñez-Sandín, MD; Pérez-Gordo, M

doi:10.18176/jiaci.0781

Cited by 7 publications

(16 citation statements)

References 15 publications

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“…These included: total Firmicutes 17,21 ; the class Clostridia 17 ; the families Lachnospiraceae 16 and Ruminococcaceae 16,17 ; the genera Clostridium , 14,19 Faecalibacterium , 16 Lactobacillus , 18 Ruminococcus 16 and Subdoligranulum 19 and the species Clostridium coccoides 15 and Clostridium celerecrescens 19 . Conversely, certain Firmicutes phylum, including the genus Granulicatella 21 and the families Streptococcaceae , 16 Enterococcaceae , 16 and Acidaminococcaceae , 20 decreased in the CMA groups. Additionally, enriched bacteria of the Firmicutes phylum, including the class Clostridia, were also observed in the infants who outgrew CMA 22 …”

Section: Resultsmentioning

confidence: 99%

“…Six studies compared α‐ and β‐diversity between CMA group and HC, three of them noted increased 16,19 or decreased 20 Shannon α‐diversity difference in the CMA groups, and one reported β‐diversity (unweighted UniFrac) difference between CMA group and HC 21 . A single study reported a higher total bacteria count in the CMA group 18 …”

Section: Resultsmentioning

confidence: 99%

“…22 Bacteroidetes phylum members also showed varying changes in the CMA groups. 14,17,[19][20][21] These included increased levels of the Flavobacteriaceae family, 17 the Bacteroides 14,19 and Prevotella 21 genera, along with reduced abundance of the Prevotellaceae family 20 and the Parabacteroides genus. 21 Furthermore, several bacteria from the Proteobacteria phylum, including the Haemophilus, Actinobacillus, and Klebsiella genera, 21 and the Escherichia coli species, 19 increased in the CMA groups.…”

Section: Case and Case-control Studiesmentioning

confidence: 99%

“…Human studies include one case and nine case-control studies (Table 1), among which four examined both the microbiome and metabolome, [14][15][16][17] five the microbiome, [18][19][20][21][22] and one the metabolome. 23 For all case-control studies, healthy controls (HC) were used except for one study 23 that considered atopic eczema/dermatitis syndrome infants as controls.…”

Section: Case and Case-control Studiesmentioning

confidence: 99%

“…GM modifications. The GM-related studies include four casecontrol reports, 15,17,19,20 four case-control findings in intervention studies, 14,16,18,21 and one case study. 22 Techniques applied for GM profile identification included bacteria culture 18 and 16S rRNA genebased approaches (DGGE, 19 FISH 14,15 and gene sequencing 16,17,[20][21][22] ).…”

Section: Case and Case-control Studiesmentioning

confidence: 99%

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Current insights into cow's milk allergy in children: Microbiome, metabolome, and immune response—A systematic review

Savova,

Zhu,

Harms

et al. 2024

Pediatric Allergy Immunology

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The increasing prevalence of IgE‐mediated cow's milk allergy (CMA) in childhood is a worldwide health concern. There is a growing awareness that the gut microbiome (GM) might play an important role in CMA development. Therefore, treatment with probiotics and prebiotics has gained popularity. This systematic review provides an overview of the alterations of the GM, metabolome, and immune response in CMA children and animal models, including post‐treatment modifications. MEDLINE, PubMed, Scopus, and Web of Science were searched for studies on GM in CMA‐diagnosed children, published before 1 March 2023. A total of 21 articles (13 on children and 8 on animal models) were included. The studies suggest that the GM, characterized by an enrichment of the Clostridia class and reductions in the Lactobacillales order and Bifidobacterium genus, is associated with CMA in early life. Additionally, reduced levels of short‐chain fatty acids (SCFAs) and altered amino acid metabolism were reported in CMA children. Commonly used probiotic strains belong to the Bifidobacterium and Lactobacillus genera. However, only Bifidobacterium levels were consistently upregulated after the intervention, while alterations of other bacteria taxa remain inconclusive. These interventions appear to contribute to the restoration of SCFAs and amino acid metabolism balance. Mouse models indicate that these interventions tend to restore the Th2/Th1 balance, increase the Treg response, and/or silence the overall pro‐ and anti‐inflammatory cytokine response. Overall, this systematic review highlights the need for multi‐omics‐related research in CMA children to gain a mechanistic understanding of this disease and to develop effective treatments and preventive strategies.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Case and Case-control Studiesmentioning

confidence: 99%

Section: Case and Case-control Studiesmentioning

confidence: 99%

Section: Case and Case-control Studiesmentioning

confidence: 99%

See 3 more Smart Citations

Current insights into cow's milk allergy in children: Microbiome, metabolome, and immune response—A systematic review

Savova,

Zhu,

Harms

et al. 2024

Pediatric Allergy Immunology

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From Bacteria to Host: Deciphering the Impact of Sphingolipid Metabolism on Food Allergic Reactions

Zubeldia-Varela,

Macías-Camero,

Pérez-Gordo

2023

Curr Treat Options Allergy

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Purpose of Review Allergic diseases have become a burden in industrialized societies. Among children, food allergy (FA) constitutes a major impairment of quality of life. FA is partly due to a lack or loss of tolerance to food antigens at the level of the intestinal mucosa, where the microbiota plays a crucial role. Early changes in the composition of the gut microbiota may influence the development of the immune system and can be related to the risk of allergic diseases, including FA. This review will focus on the role of sphingolipids and the major bacteria involved in their metabolism, in the development of food antigen sensitization and FA. Recent Findings Numerous studies have identified different patterns of microbial composition between individuals with and without FA, pointing to an interaction between gut microbiota, enterocytes, and immune cells. When this interaction is lost and an imbalance in the composition of the intestinal microbiota occurs, the integrity of the epithelial barrier may be altered, leading to intestinal permeability and sensitization to food antigens and the development of FA. Gram-negative bacteria, especially those of the Proteobacteria phylum, have been associated with the development of FA. Investigating the interactions between the intestinal microbiota and the immune system, their influence on intestinal barrier function, and their production of metabolites and signaling molecules may contribute to understanding the pathogenesis of FA. Summary Sphingolipids, a class of bioactive amphipathic lipids found in cell membranes, have emerged as critical regulators of inflammation. In this review, we will attempt to summarize the existing knowledge on the role of these molecules and the major bacteria involved in their metabolism in the mechanisms underlying sensitization to food antigens and the development of FA.

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Comparative characterization of the infant gut microbiome and their maternal lineage by a multi-omics approach

Barker-Tejeda,

Zubeldia-Varela,

Macías-Camero

et al. 2024

Nat Commun

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The human gut microbiome establishes and matures during infancy, and dysregulation at this stage may lead to pathologies later in life. We conducted a multi-omics study comprising three generations of family members to investigate the early development of the gut microbiota. Fecal samples from 200 individuals, including infants (0-12 months old; 55% females, 45% males) and their respective mothers and grandmothers, were analyzed using two independent metabolomics platforms and metagenomics. For metabolomics, gas chromatography and capillary electrophoresis coupled to mass spectrometry were applied. For metagenomics, both 16S rRNA gene and shotgun sequencing were performed. Here we show that infants greatly vary from their elders in fecal microbiota populations, function, and metabolome. Infants have a less diverse microbiota than adults and present differences in several metabolite classes, such as short- and branched-chain fatty acids, which are associated with shifts in bacterial populations. These findings provide innovative biochemical insights into the shaping of the gut microbiome within the same generational line that could be beneficial in improving childhood health outcomes.

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Unravelling the Gut Microbiota of Cow’s Milk–Allergic Infants, Their Mothers, and Their Grandmothers

Cited by 7 publications

References 15 publications

Current insights into cow's milk allergy in children: Microbiome, metabolome, and immune response—A systematic review

Current insights into cow's milk allergy in children: Microbiome, metabolome, and immune response—A systematic review

From Bacteria to Host: Deciphering the Impact of Sphingolipid Metabolism on Food Allergic Reactions

Comparative characterization of the infant gut microbiome and their maternal lineage by a multi-omics approach

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