Unravelling the immunobiology of innate lymphoid cells (ILCs): Implications in health and disease

Srivastava, Rupesh K.; Sapra, Leena; Bhardwaj, Asha; Mishra, Pradyumna K.; Verma, Bhupendra; Baig, Zainab

doi:10.1016/j.cytogfr.2023.09.002

Cited by 6 publications

(3 citation statements)

References 120 publications

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“…Natural innate lymphoid cells (ILCs) are a newly described family of immune cells that form part of natural immunity [1,2]. They lack antigen-specific receptors, which allows them to act at the earliest stages of infection.…”

Section: Introductionmentioning

confidence: 99%

“…Understanding their functions and dysregulation in various diseases may provide valuable insights for therapeutic interventions [4,5]. ILCs are distinguished by three main characteristics: (1) the absence of expression of lineage (Lin) markers, (2) the autonomy from recombination activating gene (Rag), and (3) the essential need for the common cytokine receptor γ-chain (γc) [6]. ILCs regulate immune responses, play a role in metabolic homeostasis, prevent tissue damage and tissue maintenance, and mediate responses between glial cells and other immune cells [7].…”

Section: Introductionmentioning

confidence: 99%

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Innate Lymphoid Cells and Their Role in the Immune Response to Infections

Fol,

Karpik,

Zablotni

et al. 2024

Cells

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Over the past decade, a group of lymphocyte-like cells called innate lymphoid cells (ILCs) has gained considerable attention due to their crucial role in regulating immunity and tissue homeostasis. ILCs, lacking antigen-specific receptors, are a group of functionally differentiated effector cells that act as tissue-resident sentinels against infections. Numerous studies have elucidated the characteristics of ILC subgroups, but the mechanisms controlling protective or pathological responses to pathogens still need to be better understood. This review summarizes the functions of ILCs in the immunology of infections caused by different intracellular and extracellular pathogens and discusses their possible therapeutic potential.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Innate Lymphoid Cells and Their Role in the Immune Response to Infections

Fol,

Karpik,

Zablotni

et al. 2024

Cells

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“…When allergens and harmful microorganisms enter the body, epithelial cells respond by producing and releasing cytokines such as IL-25, IL-33, and thymic stromal lymphopoietin (TSLP). These cytokines activate type II innate lymphoid cells (ILC2) and contribute to the development and maturation of Th2 cells, while, dendritic cells (DCs) activate Th2 cells in the lymph nodes in a specific manner, resulting in the production of various type II cytokines, including IL-4, IL-5, and IL-13 ( 16 – 18 ). Upon cytokine stimulation, plasma cells secrete IgE, initiating a cascade of events within the immune system ( 19 ).…”

Section: Introductionmentioning

confidence: 99%

The role of deacetylase SIRT1 in allergic diseases

Lu,

Tang,

Wang

et al. 2024

Front. Immunol.

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The silent information regulator sirtuin 1 (SIRT1) protein is an NAD+-dependent class-III lysine deacetylase that serves as an important post-transcriptional modifier targeting lysine acetylation sites to mediate deacetylation modifications of histones and non-histone proteins. SIRT1 has been reported to be involved in several physiological or pathological processes such as aging, inflammation, immune responses, oxidative stress and allergic diseases. In this review, we summarized the regulatory roles of SIRT1 during allergic disorder progression. Furthermore, we highlight the therapeutic effects of targeting SIRT1 in allergic diseases.

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The Nexus Between Traditional Chinese Medicine and Immunoporosis: Implications in the Treatment and Management of Osteoporosis

Ding,

Yang,

Wei

et al. 2024

Phytotherapy Research

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Osteoporosis (OP) is a globally prevalent bone disease characterized by reduced bone mass and heightened fracture risk, posing a significant health and economic challenge to aging societies worldwide. Osteoimmunology—an emerging field of study—investigates the intricate relationship between the skeletal and the immune systems, providing insights into the immune system's impact on bone health and disease progression. Recent research has demonstrated the essential roles played by various immune cells (T cells, B cells, macrophages, dendritic cells, mast cells, granulocytes, and innate lymphoid cells) in regulating bone metabolism, homeostasis, formation, and remodeling through interactions with osteoclasts (OC) and osteoblasts (OB). These findings underscore that osteoimmunology provides an essential theoretical framework for understanding the pathogenesis of various skeletal disorders, including OP. Traditional Chinese medicine (TCM) and its active ingredients have significant clinical value in OP treatment. Unfortunately, despite their striking multieffect pathways in the pharmacological field, current research has not yet summarized them in a comprehensive and detailed manner with respect to their interventional roles in immune bone diseases, especially OP. Consequently, this review addresses recent studies on the mechanisms by which immune cells and their communication molecules contribute to OP development. Additionally, it explores the potential therapeutic benefits of TCM and its active components in treating OP from the perspective of osteoimmunology. The objective is to provide a comprehensive framework that enhances the understanding of the therapeutic mechanisms of TCM in treating immune‐related bone diseases and to facilitate the development of novel therapeutic strategies.

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Unravelling the immunobiology of innate lymphoid cells (ILCs): Implications in health and disease

Cited by 6 publications

References 120 publications

Innate Lymphoid Cells and Their Role in the Immune Response to Infections

Innate Lymphoid Cells and Their Role in the Immune Response to Infections

The role of deacetylase SIRT1 in allergic diseases

The Nexus Between Traditional Chinese Medicine and Immunoporosis: Implications in the Treatment and Management of Osteoporosis

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