Unravelling the mechanisms of recognition and internalization of nanoparticles by cells

Abstract

Unravelling the mechanisms of recognition and internalization of nanoparticles by cells. University of Groningen.

Unveiling Nanoparticles: Recent Approaches in Studying the Internalization Pattern of Iron Oxide Nanoparticles in Mono- and Multicellular Biological Structures

“…The characteristics of nanomaterials, such as size, charge, shape, hydrophobicity, stiffness, roughness, and surface functionalization, can be modified to influence their internalization pathways. This may result in their targeting to a specific intracellular location [ 4 , 50 ]. Table 1 presents recent studies that demonstrate the diverse properties of nanoparticles that may affect their cellular uptake and the methods used to prove the internalization of the NPs, with an accent on iron oxide.…”

“…The internalization of nanosized medical devices into biological structures is a critical process for evaluating their efficiency, as well as safety for usage [ 1 , 2 , 3 ]. In the case of nanostructured systems employed in therapeutic applications targeting the death of eukaryotic or prokaryotic cell populations, it is important for the systems to be internalized into the target cells [ 1 , 4 ] so that the device can exert its therapeutic effect and achieve maximum efficiency [ 5 ].…”