Unrecovered synkinesis as a sequela of facial nerve palsy in Kawasaki disease

Rationale: Kawasaki disease (KD) manifests as an acute, self-limited vasculitis disease that constitutes the primary cause of acquired heart disease in children under 5 years of age. Facial nerve palsy (FNP) is a rare complication associated with coronary artery lesions (CALs) in patients with KD. Patients with KD and FNP usually present atypically, leading to a delayed diagnosis and treatment of KD. Patient concerns: A 4-month-old boy with fever, left FNP and bilateral conjunctival injection with spontaneous resolution, was admitted to the hospital, received a short course of intravenous dexamethasone, and experienced rapid FNP recovery on the first admission. The patient experienced a resurgence of fever, bilateral conjunctival injection, and right FNP, which led to readmission. Physical examination revealed redness at the site of Bacillus Calmette-Guérin inoculation, reddening of lips, and desquamation of the distal extremities. Echocardiography revealed right-sided CALs. Diagnoses: The patient initially missed KD on the first admission, and was later diagnosed with complete KD with FNP on the second admission. Interventions and outcomes: After a short course of intravenous dexamethasone, the left FNP resolved quickly. However, right FNP recurred after corticosteroids withdrawal. Meanwhile, more typical symptoms were observed, and KD was diagnosed. Treatment ensued with intravenous immunoglobulin (IVIG), aspirin, and dexamethasone. The patient achieved rapid remission, without recurrence. Echocardiography continued to show normal findings during 1-year follow-up after discharge. Lessons: The clinical symptoms of FNP complicating KD in children are atypical and can easily lead to delayed diagnosis and treatment. FNP in patients with KD may serve as a risk factor for CALs, which are more challenging to resolve than the FNP itself. Adding corticosteroids to IVIG may be recommended to reduce IVIG resistance, decrease the risk of developing CALs, and alleviate CALs.

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Unrecovered synkinesis as a sequela of facial nerve palsy in Kawasaki disease

Abstract: Fig. 1 Photographs of the patient. (a) Onset of left facial nerve palsy. (b-d) Six months after onset of facial nerve palsy. (b) Although the paralysis resolved, the left eyelid closed involuntarily when she opened her mouth, such as when (c) eating or (d) brushing her teeth.

Cited by 2 publications

References 4 publications

Flurbiprofen/Immune-globulin

Flurbiprofen/Immune-globulin

Bilateral facial nerve palsy complicating Kawasaki disease: A case report and literature review

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