The main features of a study dealing with partially grouted reinforced clay brick masonry wall specimens are summarized here. Results from an experimental campaign studying the inplane behavior of such partially grouted wall specimens, built using novel clay bricks with vertical holes manufactured in Greece, are presented and discussed. All wall specimens were partially grouted at specific locations hosting vertical steel reinforcement. Horizontal (shear) steel reinforcement was also included at the mortar bed joints. These specimens were rigidly attached at a reaction frame and were subjected at their top to a constant vertical load together with a horizontal seismic-type in-plane cyclic load. A key issue in the construction of these wall specimens is the masonry unit which is employed. Due to the thermal insulation requirements as well as the revisions in the provisions of the Euro-Code relevant to the seismic design and construction of unreinforced and reinforced masonry, a novel masonry unit was designed and tested. The design was based on preliminary material tests and a series of numerical simulations. The thermal insulation properties of this new unit were also taken into account in its design as well as the accommodation of the transverse horizontal joint reinforcement that was to be accommodated in a thin layer mortar joint. Summary results of all these aspects in the design and construction of this new masonry unit are present and discussed.