2000
DOI: 10.1046/j.1460-9568.2000.00199.x
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Unrelated course of subthalamic nucleus and globus pallidus neuronal activities across vigilance states in the rat

Abstract: The pallido-subthalamic pathway powerfully controls the output of the basal ganglia circuitry and has been implicated in movement disorders observed in Parkinson's disease (PD). To investigate the normal functioning of this pathway across the sleep-wake cycle, single-unit activities of subthalamic nucleus (STN) and globus pallidus (GP) neurons were examined, together with cortical electroencephalogram and nuchal muscular activity, in non-anaesthetized head-restrained rats. STN neurons shifted from a random dis… Show more

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Cited by 101 publications
(102 citation statements)
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References 98 publications
(125 reference statements)
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“…They also met international standards and were previously described in detail Urbain et al, 2000). Experiments were performed during the light part of the 12/12 h light/dark cycle.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…They also met international standards and were previously described in detail Urbain et al, 2000). Experiments were performed during the light part of the 12/12 h light/dark cycle.…”
Section: Methodsmentioning
confidence: 99%
“…A U-shaped aluminum piece, fixed to a flexible carriage (GFG Co., Pierre-Benite, France) fastened to the stereotaxic apparatus, was positioned above the VTA and lambda suture. This U-piece was then embedded in dental cement with the EEG screws and EMG wires and their six-pin connector, as already described Urbain et al, 2000Urbain et al, , 2002Urbain et al, , 2004Urbain et al, , 2006, leaving a well inside the U-piece. At the end of the surgery, the well was closed with bone wax and wound-healing cream (Madecassol, Serdex, France) was poured out on all the borders of the implant to facilitate healing.…”
Section: Methodsmentioning
confidence: 99%
“…An obvious explanation for this difference between the awake and anesthetized preparations is the relative lack of slow oscillatory activity in the cortex in the awake preparation. It is interesting to note in this context that increases in burstiness are observed in STN recordings from sleeping unanesthetized rats (Urbain et al, 2000) when slow oscillatory activity would likely be increased in the cortex. Burstiness in neuronal activity in the GP and GPi is also more evident in the primate model of PD when the monkeys are asleep (Gatev and Wichmann, 2004).…”
Section: Relevance To Awake Preparations and Faster Frequenciesmentioning
confidence: 98%
“…Their absence in the BG of Parkinson's disease patients (Brown et al, 2001) and increase in power during motor activity Cassidy et al, 2002) suggests that ␥-band oscillations are intimately related to normal motor behavior (MacKay, 1997). However, despite the anatomically identified feedback loop formed between STN and GP, the two nuclei seem decoupled in the healthy BG (Magill et al, 2000;Raz et al, 2000;Urbain et al, 2000;Baufreton et al, 2005). For example, slow (Ͻ1 Hz) cortical oscillatory activity is reflected in STN neuron output but not transmitted to GP neurons, except when dopamine has been depleted, yet, after removing both cortex and dopamine, some residual slow oscillatory activity remains in both nuclei (Magill et al, 2001).…”
Section: Introductionmentioning
confidence: 99%