1998
DOI: 10.1200/jco.1998.16.3.931
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Unrelated donor bone marrow transplantation for children and adolescents with Philadelphia-positive acute lymphoblastic leukemia.

Abstract: UD-BMT can produce prolonged disease-free survival in young patients with Ph-positive ALL who otherwise would have an extremely poor outlook.

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Cited by 68 publications
(43 citation statements)
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“…8,12,18 The overall experience of allogeneic BMT shows a disease-free survival of 20-75%, with a relapse rate ranging from 11 to 63%. [10][11][12][13][14][15] These reports include patients in various stages of remission who received autologous stem cells, or allogeneic stem cells from MRD or unrelated donors. Late relapses were seen in all the studies, independent of the type of transplant.…”
Section: Discussionmentioning
confidence: 99%
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“…8,12,18 The overall experience of allogeneic BMT shows a disease-free survival of 20-75%, with a relapse rate ranging from 11 to 63%. [10][11][12][13][14][15] These reports include patients in various stages of remission who received autologous stem cells, or allogeneic stem cells from MRD or unrelated donors. Late relapses were seen in all the studies, independent of the type of transplant.…”
Section: Discussionmentioning
confidence: 99%
“…20,21 However, 70% of patients who may benefit from allogeneic BMT lack an HLA-matched related donor, resulting in the use of alternative donor transplants for some children. [15][16][17] Unrelated BMT has been shown to offer an EFS of 38-69% in first CR. 9,10,[15][16][17] There are reports suggesting comparable outcomes of MUD BMT and MRD BMT, supporting the use of alternative donors for treating this disease.…”
Section: Discussionmentioning
confidence: 99%
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