Unreliability of Self-reported Burning Tendency and Tanning Ability

Rampen, F.H.J.; Fleuren, B A; Boo, T.M. de; Lemmens, W.A.J.G.

doi:10.1001/archderm.1988.01670060031011

Cited by 137 publications

(79 citation statements)

References 8 publications

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“…The ability to tan is central to the UVR/MS outcome hypothesis. Previous studies in patients with various diseases have shown that classifying subjects as skin types 1 or 4 is straightforward, though differentiating subjects with type 2 and 3 may be more problematic [22]. While we report an association between disability and skin type, this link was strongly determined by disease duration and gender.…”

Section: Discussioncontrasting

confidence: 53%

Studies of associations between disability in multiple sclerosis, skin type, gender and ultraviolet radiation

et al. 2007

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Recent studies suggest ultraviolet radiation (UVR)/vitamin D is protective against the development of multiple sclerosis (MS). We determined if outcome in MS is associated with the surrogate for host pigmentation, skin type, and parameters of UVR exposure. We used a validated questionnaire to determine skin type and UVR exposure during childhood (0-16 years), and early adult life (17-40 years), in 448 Caucasians with MS. Outcome was assessed using the Kurtzke Expanded Disability Status Score (EDSS) and Multiple Sclerosis Severity Scale (MSSS). We studied the association of skin type and exposure with dichotomized values of EDSS (< and >or=6) and MSSS (continuous variable) using logistic and linear regression analyses, respectively. Sex, onset age and MS duration were significantly associated with outcome in all patients. In 169 females with established disease (>or=10 years), sun sensitive skin types 1 and 2 were associated with reduced risk of EDSS >or=6 (odds ratio =0.50; 95% CI = 0.26-0.97), and higher MSSS values (coefficient = -0.86; 95% CI = -1.67 to -0.05). Parameters of UVR exposure were not significantly associated with outcome. These preliminary data show an association between skin type and disability in female MS patients. They are compatible with independent studies suggesting that exposure mediates MS pathogenesis via vitamin D. Further studies are required to properly assess these potentially important findings.

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Section: Discussioncontrasting

confidence: 53%

Studies of associations between disability in multiple sclerosis, skin type, gender and ultraviolet radiation

et al. 2007

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“…and Karlsson et al 51 . did not detect a difference in the number of CMN and in the prevalence of CAMN in relation to skin type, whereas other investigations indicated that individuals with more sun‐sensitive skin had fewer naevi 38,52–55 …”

Section: Discussionmentioning

confidence: 74%

The prevalence of melanocytic naevi among schoolchildren in South Hungary

Csoma

Erdei

Bartusek

et al. 2008

Acad Dermatol Venereol

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Our study population displayed a markedly high prevalence of clinically atypical melanocytic naevi. Moreover, a considerable proportion of the investigated individuals had multiple common melanocytic naevi. Since the presence of a large number of melanocytic naevi is a strong predictor for future melanoma development, health educational programmes on melanoma prevention should be aimed at young age groups.

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“…This finding could result from inherent difficulties in pigmentation phenotyping, for example skin typing based on historical data, provided by the study subject, is prone to error (Rampen et al, 1988;Weinstock et al, 1991). However, some researchers have interpreted the results of these studies as suggesting the MC1R variants alter skin cancer development and/or progression through mechanisms which are independent of their effects on pigmentation.…”

Section: Introductionmentioning

confidence: 99%

Human melanocortin 1 receptor (MC1R) gene variants alter melanoma cell growth and adhesion to extracellular matrix

Robinson

Healy

2002

Oncogene

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Pigmentation is a significant determinant of individual susceptibility to cutaneous melanoma, with fair skinned subjects at highest risk of developing this neoplasm. Melanocortin 1 receptor (MC1R) gene variants alter pigment synthesis in vivo, and are causally associated with red hair and fair skin in humans. MC1R variants are more frequent in subjects with melanoma, and increase the risk of developing this tumour in sporadic and familial cases. MC1R variants may predispose to melanoma as a result of alterations in skin pigmentation (which affords less protection against incident ultraviolet radiation). However, melanoma cells synthesize and release alpha-melanocyte stimulating hormone (aMSH, the ligand for MC1R), therefore MC1R variants could alter the autocrine effects of aMSH on melanoma cell behaviour, thereby affecting early melanoma development and progression via non-pigmentary mechanisms. B16G4F melanoma cells, which are functionally null at Mc1r, were stably transfected with wild type and variant (Arg151Cys, Arg160Trp, and Asp294His) human MC1R. At similar MC1 receptor numbers per cell, aMSH increased intracellular cAMP in wild type MC1R transfected melanoma cells, but the cAMP response was compromised in the variant MC1R transfected clones. In growth inhibition experiments, aMSH significantly reduced growth of wild type MC1R transfected cells, but had no effect on cells transfected with variant MC1R. In addition, binding to fibronectin was significantly reduced by aMSH in the wild type transfectants whereas this was not observed in the variant transfected clones; binding to laminin was not affected by aMSH in this cell line. These results provide evidence for differences in melanoma cell behaviour secondary to MC1R variants, and suggest an alternative non-pigmentary mechanism whereby MC1R variants could modify melanoma susceptibility or progression.

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Unreliability of Self-reported Burning Tendency and Tanning Ability

Cited by 137 publications

References 8 publications

Studies of associations between disability in multiple sclerosis, skin type, gender and ultraviolet radiation

Studies of associations between disability in multiple sclerosis, skin type, gender and ultraviolet radiation

The prevalence of melanocytic naevi among schoolchildren in South Hungary

Human melanocortin 1 receptor (MC1R) gene variants alter melanoma cell growth and adhesion to extracellular matrix

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