Unresolved Systemic Inflammation, Long COVID, and the Common Pathomechanisms of Somatic and Psychiatric Comorbidity

Liang, Chih‐Sung; Gałecki, Piotr; Su, Kuan‐Pin

doi:10.3390/jcm11175114

Cited by 11 publications

(4 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The neuropsychiatric sequelae of long COVID are multifactorial. The development of depression and other psychiatric symptoms of long COVID may involve several different mechanisms, including direct brain infection and neuro-injury by SARS-CoV-2, unresolved systemic inflammation and ensuing increased inflammation in the brain through compromised blood-brain barrier (BBB), and oxidative stress [ 7 , 35 , 37 , 38 ]. They may operate alone or together, leading to the development of depression, cognitive impairments, and other psychiatric sequelae (sleep disturbances, fatigue) in COVID-19 survivors.…”

Section: Could the Inflammation Theory Of Depression Apply To Long Co...mentioning

confidence: 99%

“…Long COVID can involve multiple organs and systems, including the immune system, pulmonary system, cardiovascular system, gastrointestinal system, liver, kidney, pancreas, spleen, and the brain [ 4 - 7 ]. The clinical manifestations of long COVID encompass a multitude of symptoms with the symptom severity and duration varying substantially.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Clinical Observation of Inflammation Theory for Depression: The Initiative of the Formosa Long COVID Multicenter Study (FOCuS)

Liu

Lin

Chang

et al. 2023

Clin Psychopharmacol Neurosci

Self Cite

View full text Add to dashboard Cite

There is growing evidence that the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with increased risks of psychiatric sequelae. Depression, anxiety, cognitive impairments, sleep disturbance, and fatigue during and after the acute phase of COVID-19 are prevalent, long-lasting, and exerting negative consequences on well-being and imposing a huge burden on healthcare systems and society. This current review presented timely updates of clinical research findings, particularly focusing on the pathogenetic mechanisms underlying the neuropsychiatric sequelae, and identified potential key targets for developing effective treatment strategies for long COVID. In addition, we introduced the Formosa Long COVID Multicenter Study (FOCuS), which aims to apply the inflammation theory to the pathogenesis and the psychosocial and nutrition treatments of post-COVID depression and anxiety.

show abstract

Section: Could the Inflammation Theory Of Depression Apply To Long Co...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Clinical Observation of Inflammation Theory for Depression: The Initiative of the Formosa Long COVID Multicenter Study (FOCuS)

Liu

Lin

Chang

et al. 2023

Clin Psychopharmacol Neurosci

Self Cite

View full text Add to dashboard Cite

show abstract

“…Systemic, endothelial, and neuroinflammatory processes, along with reactivation of latent pathogens are suspected contributors to PCS development. However, the immunological and pathological mechanisms of PCS remain unclear and specific treatment options are scarce [ 9 ]. Importantly, due to the large number of individuals faced with this condition, PCS considerably impacts communities and health care systems worldwide [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluating the Feasibility, Acceptance, and Beneficial Effects of Online Occupational Therapy for Post–COVID-19 Condition: Protocol for a Randomized Controlled Trial (ErgoLoCo Study)

Müllenmeister,

Stoelting,

Schröder

et al. 2024

JMIR Res Protoc

View full text Add to dashboard Cite

Background Post–COVID-19 syndrome (PCS; also known as “long COVID”) is a relatively novel disease comprising physical, psychological, and cognitive complaints persisting several weeks to months after acute infection with SARS-CoV-2. Approximately 10% of patients with COVID-19 are affected by long-term symptoms. However, effective treatment strategies are lacking. The ErgoLoCo (Occupational Therapy [Ergotherapie] for Long COVID) study was designed to develop and evaluate a novel occupational therapy (OT) concept of online delivery of therapy for long COVID. Objective The primary study objective is to assess the feasibility of the online OT intervention in PCS. Secondary aims include the evaluation of online OT concerning cognitive problems, occupational performance, and social participation. Methods This randomized controlled interventional pilot study involves parallel mixed methods process analyses and a realist evaluation approach. A total of 80 clients with PCS aged at least 16 years will be recruited into two interventional groups. The control cohort (watch and wait) comprises 80 clients with long COVID. Treatment is provided through teletherapy (n=40) or delivery of prerecorded videos (n=40) using the same standardized OT concept twice weekly over 12 weeks. Analyses of quantitative questionnaires and qualitative interviews based on the theoretical framework of acceptability will be performed to assess feasibility. Focus group meetings will be used to assess how acceptable and helpful the intervention was to the participating occupational therapists. Standardized tests will be used to assess the initial efficacy of the intervention on neurocognitive performance; limitations in mobility, self-care, and everyday activities; pain; disabilities; quality of life (QoL); social participation; and anxiety and depression in PCS, and the possible effects of online OT on these complaints. Results The German Ministry of Education and Research provided funding for this research in March 2022. Data collection took place from October 2022 to August 31, 2023. Data analysis will be completed by the end of April 2024. We anticipate publishing the results in the fall of 2024. Conclusions Despite the enormous clinical need, effective and scalable treatment options for OT clients who have PCS remain scarce. The ErgoLoCo study will assess whether online-delivered OT is a feasible treatment approach in PCS. Furthermore, this study will assess the effect of the intervention on cognitive symptoms, QoL, and occupational performance and participation in everyday life. Particular emphasis will be placed on the experiences of clients and occupational therapists with digitally delivered OT. This study will pave the way for novel and effective treatment strategies in PCS. Trial Registration German Clinical Trial Registry DRKS00029990; https://drks.de/search/de/trial/DRKS00029990 International Registered Report Identifier (IRRID) PRR1-10.2196/50230

show abstract

“…Depression affects over 280 million people globally according to the World Health Organization (WHO, 2023), and is the second leading cause of disability worldwide after cancer, while predicted to be the leading cause by 2030 ( Malhi and Mann, 2018 ). In the post-COVID-19 era, mental and behavioral disorders are reported to have become more severe, possibly due to the pandemic effects on healthcare and the economy worldwide ( Liang et al, 2022 ; Poletti et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Integrative bioinformatics and artificial intelligence analyses of transcriptomics data identified genes associated with major depressive disorders including NRG1

Bouzid,

Almidani,

Zubrikhina

et al. 2023

Neurobiology of Stress

View full text Add to dashboard Cite

Unresolved Systemic Inflammation, Long COVID, and the Common Pathomechanisms of Somatic and Psychiatric Comorbidity

Abstract: Monoamine hypothesis is an overestimated hypothesis of major depressive disorder (MDD), and the treatments and biomarkers that target it only show modest effect in randomized controlled trials (RCTs) or case–control studies [...]

Cited by 11 publications

References 33 publications

The Clinical Observation of Inflammation Theory for Depression: The Initiative of the Formosa Long COVID Multicenter Study (FOCuS)

The Clinical Observation of Inflammation Theory for Depression: The Initiative of the Formosa Long COVID Multicenter Study (FOCuS)

Evaluating the Feasibility, Acceptance, and Beneficial Effects of Online Occupational Therapy for Post–COVID-19 Condition: Protocol for a Randomized Controlled Trial (ErgoLoCo Study)

Integrative bioinformatics and artificial intelligence analyses of transcriptomics data identified genes associated with major depressive disorders including NRG1

Contact Info

Product

Resources

About