Unrestricted molecular motions enable mild photothermy for recurrence-resistant FLASH antitumor radiotherapy

Shen, Hanchen; Wang, Hongbin; Mo, Jianlan; Zhang, Jianyu; Xu, Changhuo; Sun, Feiyi; Ou, Xinwen; Zhu, Xinyan; Du, Lidong; Ju, Huaqiang; Ye, Ruquan; Shi, Guangfu; Kwok, Ryan T.K.; Lam, Jacky W.Y.; Sun, Jianwei; Zhang, Tianfu; Ning, Shipeng; Tang, Ben Zhong

doi:10.1016/j.bioactmat.2024.03.024

Bioactive Materials

2024

DOI: 10.1016/j.bioactmat.2024.03.024

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Unrestricted molecular motions enable mild photothermy for recurrence-resistant FLASH antitumor radiotherapy

Hanchen Shen,

Hongbin Wang,

Jianlan Mo

et al.

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Cited by 3 publications

References 63 publications

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BOIMPY Scaffold: Accessing Ultrahigh Molar Extinction Coefficient AIEgen for SWIR Imaging‐Guided Photothermal Cancer Ablation

Yang,

Ou,

Zhang

et al. 2024

Adv Funct Materials

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Despite the extensive reporting of versatile aggregation‐induced emission luminogens (AIEgens), boosting their molar extinction coefficient (MEC, ε ≈ 103–104 M−1cm−1) remains a formidable challenge, which poses a significant obstacle to achieving the ceiling of their output performance. In this work, an “aggrandizing absorption reservoir” approach is proposed to designing AIEgens with remarkable photons‐harvesting ability, ultimately enlarging its output performance in terms of short‐wave infrared (SWIR, 900–1700 nm) emission and photothermal effect. For the first time, the (bis‐(borondifluoride)‐8‐imidazodipyrromethene) (BOIMPY) unit, which provides sufficient rigidity and strong electron‐withdrawing ability by employing benzimidazole as a bridging ligand binding two BF2 units, is utilized to fabricate novel AIEgen (TPEB) that exhibits an ultrahigh MEC up to 1.29 × 105 M−1 cm−1 at 828 nm. To the best of knowledge, this is the highest MEC reported among AIEgens with near‐infrared absorption. Thanks to its remarkable photon‐harvesting ability, TPEB exhibits strong fluorescence in the SWIR region and a good photothermal effect. The as‐prepared TPEB NPs are successfully applied for SWIR imaging‐guided photothermal antitumor therapy. The proposed “aggrandizing absorption reservoir” approach provides a novel guideline for designing versatile AIEgens for biomedical applications.

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BOIMPY Scaffold: Accessing Ultrahigh Molar Extinction Coefficient AIEgen for SWIR Imaging‐Guided Photothermal Cancer Ablation

Yang,

Ou,

Zhang

et al. 2024

Adv Funct Materials

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Two‐Photon Clusteroluminescence Enabled by Through‐Space Conjugation for In Vivo Bioimaging

Zhang,

Shen,

Xiong

et al. 2024

Angewandte Chemie

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Clusteroluminescence (CL) materials without largely conjugated structures have gained significant attention due to their unique photophysical properties and potential in bioimaging. However, low luminescence efficiency and short emission wavelength limit their development. This work designs three luminogens with CL properties (CLgens) by introducing n‐electron‐involved through‐space conjugation (TSC) into diarylmethane. Apart from single‐photon excited long‐wavelength (688 nm) and high‐efficiency (29%) CL, two‐photon clusteroluminescence (TPCL) is successfully achieved in such small luminogens with only two isolated heteroatomic units. TSC stabilized in the aggregate state has been proven to realize efficient spatial electron delocalization similar to conventionally conjugated compounds. Encouraged by the excellent TPCL properties, two‐photon imaging of blood vessels in vivo and biocompatibility verification utilizing CLgens are also achieved. This work illustrates the essential role of TSC in promoting nonlinear optical properties of CLgens and may facilitate further design and development of the next generation of bioprobes with excellent biocompatibility.

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Reengineering of Donor–Acceptor–Donor Structured Near-Infrared II Aggregation-Induced Emission Luminogens for Starving-Photothermal Antitumor and Inhibition of Lung Metastasis

Yang,

Wang,

et al. 2024

ACS Nano

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Electron acceptor possessing strong electron-withdrawing ability and exceptional stability is crucial for developing donor−acceptor−donor (D-A-D) structured aggregation-induced emission luminogens (AIEgens) with second near-infrared (NIR-II) emission. Although 6,7-diphenyl-[1,2,5] thiadiazolo [3,4g] quinoxaline (PTQ) and benzobisthiadiazole (BBT) are widely employed as NIR-II building blocks, they still suffer from limited electron-withdrawing capacity or inadequate chemo-stability under alkaline conditions. Herein, a boron difluoride formazanate (BFF) acceptor is utilized to construct NIR-II AIEgen, which exhibits a better overall performance in terms of NIR-II emission and chemo-stability compared to the PTQ-and BBT-derived fluorophores. With finely tuned intramolecular motions and strong D−A interaction strength, TPE-BFF simultaneously exhibits high molar extinction coefficient (ε= 4.31 × 10 4 M −1 cm −1 ), strong NIR-II emission (Φ = 0.49%) and photothermal effect (η = 58.5%), as well as high stability. Thanks to these merits, the thermosensitive nanoparticles constructed by integrating TPE-BFF and the antiglycolytic agent 2-deoxy-D-glucose (2DG) are successfully utilized for imaging-guided photothermal antitumor lung metastasis by regulating glycolysis and reducing ATP-dependent heat shock proteins. Combining experimental results and theoretical calculations, BFF proves to be an outstanding electron acceptor for the design of versatile NIR-II AIEgens. Overall, this study offers a promising alternative for developing multifunctional NIR-II AIEgens in biomedical applications.

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Unrestricted molecular motions enable mild photothermy for recurrence-resistant FLASH antitumor radiotherapy

Cited by 3 publications

References 63 publications

BOIMPY Scaffold: Accessing Ultrahigh Molar Extinction Coefficient AIEgen for SWIR Imaging‐Guided Photothermal Cancer Ablation

BOIMPY Scaffold: Accessing Ultrahigh Molar Extinction Coefficient AIEgen for SWIR Imaging‐Guided Photothermal Cancer Ablation

Two‐Photon Clusteroluminescence Enabled by Through‐Space Conjugation for In Vivo Bioimaging

Reengineering of Donor–Acceptor–Donor Structured Near-Infrared II Aggregation-Induced Emission Luminogens for Starving-Photothermal Antitumor and Inhibition of Lung Metastasis

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