Unruptured Intracranial Aneurysms: Some Questions Answered, Many Questions Remain

Brown, Robert D.; Torner, James C.

doi:10.1017/s0317167100017984

Cited by 5 publications

(1 citation statement)

References 27 publications

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“…7 There are various modifiable and non-modifiable risk factors associated with intracranial aneurysm development and rupture. [8][9][10] Non-modifiable factors include older age, women, history of prior aneurysm or subarachnoid haemorrhage, family history of intracranial aneurysm or subarachnoid haemorrhage, and Finnish or Japanese ethnicity. Modifiable factors include hypertension, smoking, and excess alcohol intake.…”

Section: Discussionmentioning

confidence: 99%

Fourteen intracranial aneurysms in a single patient—the largest number ever reported in the literature

Mohamed Rafi,

Periyakappan

2024

IJNMHS

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A 52-year-old female came with complaints of intense headaches for the past 10 days. The CT brain revealed SAH in the bilateral Sylvain fissure (left more than right) with Hunt and Hess Grade 1. An urgent CT cerebral angiogram was done, which revealed multiple bilateral MCA, ACA, and basilar top aneurysms. DSA was done the next day, which revealed multiple aneurysms, a total of fourteen in number. Such multiple aneurysms in a single patient were never reported in the literature until now, according to the present author's knowledge.

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Section: Discussionmentioning

confidence: 99%

Fourteen intracranial aneurysms in a single patient—the largest number ever reported in the literature

Mohamed Rafi,

Periyakappan

2024

IJNMHS

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Was ist gesichert in der Therapie der autosomal-dominanten polyzystischen Nierenerkrankung?

Wulfmeyer

Schmitt

2021

Internist

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Polycystic kidney disease

Bergmann

Guay‐Woodford

Harris

et al. 2018

Nat Rev Dis Primers

559

509

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Cystic kidneys are common causes of end-stage renal disease, both in children and in adults. Autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive polycystic kidney disease (ARPKD) are cilia-related disorders and the two main forms of monogenic cystic kidney diseases. ADPKD is a common disease that mostly presents in adults, whereas ARPKD is a rarer and often more severe form of polycystic kidney disease (PKD) that usually presents perinatally or in early childhood. Cell biological and clinical research approaches have expanded our knowledge of the pathogenesis of ADPKD and ARPKD and revealed some mechanistic overlap between them. A reduced ‘dosage’ of PKD proteins is thought to disturb cell homeostasis and converging signalling pathways, such as Ca2+, cAMP, mechanistic target of rapamycin, WNT, vascular endothelial growth factor and Hippo signalling, and could explain the more severe clinical course in some patients with PKD. Genetic diagnosis might benefit families and improve the clinical management of patients, which might be enhanced even further with emerging therapeutic options. However, many important questions about the pathogenesis of PKD remain. In this Primer, we provide an overview of the current knowledge of PKD and its treatment.

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Unruptured Intracranial Aneurysms: Some Questions Answered, Many Questions Remain

Cited by 5 publications

References 27 publications

Fourteen intracranial aneurysms in a single patient—the largest number ever reported in the literature

Fourteen intracranial aneurysms in a single patient—the largest number ever reported in the literature

Was ist gesichert in der Therapie der autosomal-dominanten polyzystischen Nierenerkrankung?

Polycystic kidney disease

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