Unsaturated fatty acid composition in serum phospholipids in patients in the acute phase of myocardial infarction

Dietary intake of omega fatty acids and polyphenols and its relationship with the levels of inflammatory markers in men with chronic coronary syndrome after percutaneous coronary intervention

“…Patients with myocardial infarction had a significantly higher omega-6 / omega-3 ratio than those at cardiovascular risk. 35 Ferrucci et al 36 studied the relationship between plasma PUFAs and circulating inflammatory markers in 1123 individuals aged 20 to 98 years in a community -based sample. The total amount of omega-3 fatty acids was independently associated with lower levels of proinflammatory markers (interleukin [IL] 6, IL-1 receptor antagonist, tumor necrosis factor α, and CRP) and higher levels of anti -inflammatory markers (soluble IL-6 receptor, IL-10, and transforming growth factor α), independent of confounders.…”

Palmitic acid increases HCK protein and gene expression levels in vascular smoot muscle cells

“…Some reports have shown that the palmitic acid develops the risk of cardiovascular diseases (4)(5)(6). In another study, the serum palmitic acid-related phospholipid fraction was reported to involve with myocardial infarction (7).…”

Serum phospholipid cis-palmitoleic acid in patients with type 2 diabetes and chronic coronary syndrome: an assessment of the relationship with diabetes duration, systemic low-grade inflammation and circulating oxidized low-density lipoprotein

“…1,2,5 However, data from clinical studies are not conclusive. 1,2, 5,6 Little is known about the role of POA in the pathogenesis of T2D complications, including diabetic macroangiopathy.…”

“…Experimental and clinical studies showed that MUFAs have multiple beneficial effects on cardiovascular health and glucose homeostasis. 6 Although the POA content in the average Western diet is low or very low, POA is the second most widespread MUFA, after oleic acid, in fatty tissue and serum phospholipids. 1-5 It has been shown that the content of POA in serum phospholipids depends mainly on the hepatic activity of SCD1.…”

“…Results and discussion Individuals with POA less than 14.9 µmol/l, compared with patients with POA of 14.9 µmol/l or greater had similar clinical and demographic characteristics, except for longer diabetes duration (median [IQR], 11 [8][9][10][11][12][13][14][15][16][17][18][19][20] vs 8 [5][6][7][8][9][10] years; P = 0.01) and lower prevalence of obesity (54.1% vs 78.4%; P = 0.03) (Supplementary material, Table S1). Patients with POA of 14.9 µmol/l or greater had higher levels of insulin, C -peptide, triglycerides, and estimated SCD1 activity (TAblE 1).…”