Unsaturated fatty acids as cytoprotective agents in the pancreatic β-cell

Morgan, Noel G.; Dhayal, Shalinee

doi:10.1016/j.plefa.2010.02.018

Cited by 57 publications

(56 citation statements)

References 66 publications

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“…Unlike PUFA, MUFA are not precursors to prostaglandin. In fact, in contrast to the former class, MUFA appear to act as cytoprotective agents in beta cells (Morgan and Dhayal, 2010).…”

Section: The Cyclooxygenase Pathwaymentioning

confidence: 92%

Hormetic and regulatory effects of lipid peroxidation mediators in pancreatic beta cells

Maulucci

Daniel

Cohen

et al. 2016

Molecular Aspects of Medicine

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“…Unlike PUFA, MUFA are not precursors to prostaglandin. In fact, in contrast to the former class, MUFA appear to act as cytoprotective agents in beta cells (Morgan and Dhayal, 2010).…”

Section: The Cyclooxygenase Pathwaymentioning

confidence: 92%

Hormetic and regulatory effects of lipid peroxidation mediators in pancreatic beta cells

Maulucci

Daniel

Cohen

et al. 2016

Molecular Aspects of Medicine

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“…1 In in vitro and animal models, palmitic acid (16 : 0) is considered the main culprit of SFA impairing pancreatic b-cell function and insulin sensitivity, whereas the major dietary MUFA oleic acid (18 : 1n À 9) is protective for b-cells and insulin target tissues. 2,3 In previous studies, we have shown that consumption of meals rich in dietary fats with a high MUFA-to-SFA ratio may decrease exacerbated insulin excursion and increase insulin sensitivity in the postprandial period in subjects with normal fasting triglycerides. 4 Similar ndings were observed in subjects with high fasting triglycerides when meals enriched in SFA and MUFA were compared.…”

Section: Introductionmentioning

confidence: 99%

Clustering effects on postprandial insulin secretion and sensitivity in response to meals with different fatty acid compositions

et al. 2014

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Dietary fatty acids play a role in glucose homeostasis. The aim of this study was to assess the individual relationship between dietary saturated (SFA), monounsaturated (MUFA) and polyunsaturated (PUFA) fatty acids with postprandial β-cell function and insulin sensitivity in subjects with normal and high fasting triglycerides. We assessed postprandial β-cell function (by the insulinogenic index and the ratio of the insulin to glucose areas under the time-concentration curve) and insulin sensitivity (by the oral glucose and the minimal model insulin sensitivity indices) over four nonconsecutive, randomly assigned, high-fat meals containing a panel of SFA (palmitic and stearic acids), MUFA (palmitoleic and oleic acids) and PUFA (linoleic and α-linolenic acids) in 14 subjects with normal and in 14 subjects with high fasting triglycerides. The proportions of each fatty acid in the meals and the values for surrogate measures of postprandial β-cell function and insulin sensitivity were subjected to a Pearson correlation and hierarchical cluster analysis, which revealed two classes of dietary fatty acids for regulating postprandial glucose homeostasis. We successfully discriminated the adverse effects of SFA palmitic acid from the beneficial effects of MUFA oleic acid on postprandial β-cell function (r ≥ 0.84 for SFA palmitic acid and r ≥ -0.71 for MUFA oleic acid; P < 0.05) and insulin sensitivity (r ≥ -0.92 for SFA palmitic acid and r ≥ 0.89 for MUFA oleic acid; P < 0.001) both in subjects with normal and high fasting triglycerides. In conclusion, dietary MUFA oleic acid, in contrast to SFA palmitic acid, favours the tuning towards better postprandial glycaemic control in subjects with normal and high fasting triglycerides.

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“…This in turn reduces the putative regulatory pool of intracellular free cholesterol, increasing LDL receptor activity and subsequently decreasing circulating cholesterol concentrations (Griel et al, 2008). Palmitoleic acid has also been shown to prevent b-cell apoptosis induced by glucose or saturated fatty acids beta-cells or pancreas secrete insulin and their programmed death or apoptosis leads to type-2 diabetes) (Morgan and Dhayal, 2010). Palmitoleic acid-rich diets have also been reported to improve circulating lipid profile, resulting in reduced total and LDL cholesterol (Griel et al, 2008).…”

Section: Introductionmentioning

confidence: 99%